18 women with bilateral paralysis of the larynx were taken into the study. 14 of them were tracheotomized, 4 - not. All the patients were divided into two groups. In the first group 9 patients had chordaritinoidotomy with Coblator apparatus. In the second group 9 patients had the same surgery with microsurgical tools. After the surgery, all patients had anti-inflammatory therapy; 5 patients in each group had additional laser therapy at the projection of larynx cartilage with laser device «Mustang 2 000». On days 3 and 10 after the surgery, patients were examined with Doppler flowmetry considering the variation coefficient (Kv). On the third day, 4 patients in each group who were no treated with laser therapy had Kv equal to 9 units, while in 10 patients who had laser therapy it was 13 units. On day 10, Kv in the first group was 26 units; in the second - 32 units. In both groups 4 months later the researchers registered complications: cicatricial stenosis of the subfold area and vocal cords, a polyp in the vocal folds. On the opposite, 10 patients from the laser-treated group had no any complications. It has been found out that laser therapy is an important factor for the activation of regenerative processes in the postoperative area.

Outcomes after laser therapy in patients with intervertebral disk hernias and the faset-syndrome are presented in the article. The applied techniques are minimally invasive punctures - percutaneous laser decompression of intervertebral discs (PLDD) and percutaneous laser destruction of facet nerves with laser light having wavelength of 1.06, 0.97 and 1.55 μm. If these techniques are applied under correct indications, stable positive results may be obtained in 97% of cases.

This study included 276 patients with various forms of acne vulgaris (AV) aged 16-44. Most of them had a severe AV form and disease duration from 1 to 5 years. Patients were divided into two groups: Group I - controls (39) treated traditionally, and Group II - studied (237) who had a combined LLLT + PDT treatment by the technique developed by the authors. It has been shown that AV disease is accompanied with the excessive secretion of components of the proinflammatory cytokine system: IL-1a, IL-2, IL-8, TNFa and VEGF reparation marker which develops under the reduced anti-inflammatory mediators: IL-4, IL-10, IFNy indicating the activation of the inflammatory reaction and insufficient functional anti-inflammatory activity of the immune system and clinically correlated (r = +0.89) persistent torpid disease course. It has been established, with a high degree of reliability (p < 0.01), that the developed innovative technique and a step-by-step algorithm of treatment of AV patients with combined LLLT + PDT leads to the correction and restoration of the proper balance of pathogenetically significant cytokinetic (pro- and anti-inflammatory) components of the immune status providing a systemic pronounced immunomodulatory effect. It has been revealed as well that this effect correlates directly and highly reliably (r = +0.84) with the operative regression of specific skin rash and with a much longer remission and a significant reduction in the number of relapses of the disease in AV patients treated with LLLT + PDT as compared to the controls who were treated with traditional therapy.

Many factors are involved in the pathogenesis of rheumatoid arthritis including endocrine ones. The aim of the present work was to study effects of low level laser irradiation at the dynamics of melatonin, cortisol and some indicators of microcirculation in patients with rheumatoid arthritis. The authors examined 128 patients with rheumatoid arthritis aged 18-75. 96 patients (studied group) had a 10-day course of intravenous laser therapy every other day with Matrix-VLOK laser apparatus (Matrix firm, Russia) having two emitting heads: KL-VLOK with wavelength 0.63 μm, power at the end of the tip 1.5-2.0 mV, exposure 15 minutes and KL-VLOK-365 with wavelength of 0.365 μm, power at the end of the tip 1.5-2.0 mV, exposure 5 minutes in continuous mode. The intravenous laser therapy course lasted for 10 days without any intervals for the weekend. The studied parameters were assessed before and after treatment. Patients with rheumatoid arthritis who had the course of intravenous laser therapy in addition to traditional therapy demonstrated the decrease of melatonin level, the increase in cortisol level and better mirocirculation.

Purpose. To increase the effectiveness of reparative processes in the nasal mucous after septoplasty and submucous vasotomy of lower nasal cavities by applying monochrome incoherent radiation of blue light of the spectrum (λ - 450 nm), i. e. by photochromotherapy. The study included 50 patients with nasal septum deviation and vasomotor rhinitis who had simultaneous septoplasty and submucosal vasotomy in lower nasal cavities. All patients were divided into two groups: main and control. Patients from the control group had standard postoperative therapy, while patients from the main group in addition to the standard postoperative therapy had photochromotherapy (λ - 450 nm) staring from day 2 after the surgery. Patients’ examination included: endoscopy of nasal cavity, assessment of transport, excretory and suction functions of the nasal mucous as well as cytological examination and anterior active rhinomanometry. The research performed has revealed that irradiation of the nasal cavity with monochrome incoherent radiation, having wavelength λ - 450 nm, promotes stimulation of reparative processes in the nasal mucous.

Purpose. To develop an integrated approach to the management of pre-exisiting and precancerous diseases of the vulva using PDT and plasma therapy as a restorative therapy and to evaluate the effectiveness of such approach. Material and methods. 20 female patients aged 34-69 were divided into two groups. All patients had PDT with intravenous photosensitizers of chlorine raw «Pho-toditazine» or «Radachlorin». Laser devices for PDT «Elomed» and «Milon» generating laser light with wavelength of 662 nm were used as light sources. Laser beam was delivered via light guides having microlens at their end. Patients of the 2nd group had plasma therapy after PDT. Results. It has been found out that PDT and plasma therapy improve outcomes in pre-existing and precancerous diseases of the vulva increasing a disease-free period.

The aim of the present study was to develop techniques for minim ally invasive treatment and prophylactics of intrauterine synechias in women of the reproductive age having uterine infertility. The work was done at the Department of Obstetrics and Gynecology No. 1 in the First Moscow State Medical University named after Sechenov. 86 patients of reproductive age with intrauterine synechias and infertility aged 23-45 were divided into 3 groups. All patients were examined and treated. Patients from the first group had hysteroscopy, laser destruction of intrauterine synechias and anti-adhesive gel injections; in the second group, women had hysteroscopy and laser destruction of adhesions; in the third group, patients had instrumental destruction of synechias with Hegar's dilators and curettes. In the postoperative period, all patients were prescribed angioprotective, anti-inflammatory and hormone therapy. If patients had a marked adhesive process, they were prescribed laser therapy and physiotherapy. In 3-6 months after the described manipulations, patients had a diagnostic hysteroscopy. All patients with recurrent intrauterine synechias were prescribed a repeated hysteroscopy, laser destruction of intrauterine synechias and anti-adhesive gel injections. As it has been shown, little-traumatic techniques and prophylactics of intrauterine synechias with laser surgery and anti-adhesive gel to patients with uterine infertility helped to restore the uterine cavity with the followed pregnancy in 52% of women from the first group, while in the second and third groups pregnancy developed in 25% and 16.7%, respectively.

The present study attempts to identify the relationship between morphological structures of the liquid portion of blood and impaired deformability of red blood cells in 56 patients with bronchial asthma (BA) at incomplete remission and at an acute stage before and after the blue light photohemotherapy. It has been found out that in patients with different BA phenotypes, solid phase structures of blood serum «lipid-protein» systems have specific features before their exposure to blue light, while the erythrocyte deformability in all studied patients is impaired to the same degree. After the blue light photohemotherapy, changes in the morphological structure of blood serum in both groups corresponded to the objective improvement in patients’ condition; however, it did not reflect the dependence between blood serum structures specific for BA definite genotype and increasing deformability in red blood cells in the same groups of patients.

The researchers created an experimental model of a chronic granulating liquor fistula in rats. 90 animals with CSF fistulas were divided into 2 groups: main and control with 45 animals each. In the main group fistula walls were exposed to high-level laser light (laser device «IRE-Polus», wavelength 970 nm, lightguide diameter 0.4 mm, power 0.7W, exposure 5 seconds). The obliteration process in fistulas was assessed in dynamics within one month using standard morphological techniques with morphometry. Experimental animals were examined immediately after the catheter removal and in 1, 3, 7, 14, 21, 30 days. The lumen of fistulas was closed in 14 days in the main group after laser irradiation and in 21 days in the controls. More rapid healing in the main group is explained by the reduced component of hemorrhagic inflammation and less cell infiltration in fistula walls as well as by more intensive increase in fibroblast level and collagen fibers what had been seen since the 7th day. The researchers also observed more rapid maturation of granulation tissue in the fistula area. One month later, a significant increase of micro vascular area in specimens was found in the experimental group, indicating a better formation of vessels in the microcirculatory flow, as compared to the controls.

Purpose. To optimize treatment of patients with purulent wounds in soft tissues of various genesis using laser photodynamic therapy (PDT). Material and methods. The authors have analyzed results of complex examination and management of 125 patients with purulent wounds in soft tissues of various genesis. In the control group, patients had traditional topical therapy of wounds with antiseptics of various physical forms depending on the phase of wound process. Patients from the studied group has laser PDT with microcupsulated 0.1% Photoditazine preparation complexed with amphiphilic polymers and hydroxyapatite in a gel form. The researchers studied the dynamics of wound process depending of the process phase. Results. PDT of purulent wounds using Photoditazine complexed with amphiphilic polymers and hydroxyapatite in gel and microcupsulated forms causes marked activation of processes purifying wound of necrotized tissues, fibrin and microorganism colonies in the zone of primary wound canal. Conclusion. Photodynamic therapy of purulent wounds in soft tissues with Photoditazine complexed with amphiphilic polymers and hydroxyapatite in gel and microcupsulated forms is highly effective, and far exceeds traditional techniques as it has been proven by clinical, cytological, histological and bacteriologic examinations.

The present literature review analyzes modern laser techniques used for the endoscopic examination of the colon. The recently appeared diagnostic techniques, such as autofluorescent diagnostics, photodynamic diagnostics, optical coherence tomography, confocal laser endomicroscopy and blue laser imaging, have significantly increased the value of endoscopic examinations. The authors assess the effectiveness of modern laser technologies in endoscopic diagnostics of colon neoplasms. The goal of autofluorescent diagnostics and photodynamic diagnostics is to detect superficial epithelial structures with optical filters and post-computer image processings. Differential diagnostics of neoplasms became possible due to optical coherence tomography and confocal laser endomicroscopy. The authors have also analyzed the effectiveness of laser techniques in endoscopic diagnostics of colon neoplasms. Endoscopic laser diagnostic techniques increase the accuracy in detecting colon neoplasms. These techniques, being applied in clinical practice, open new horizons in clinical endoscopy.