Objective: To evaluate the effectiveness of local low-level laser irradiation with wavelength 635 nm in the complex therapy of candidal lesions of mucous membranes in the urogenital system.

Material and methods. Clinical picture, factors of the congenital immunity in 100 women with verified diagnosis of inflammatory disease caused by yeast-like fungi of the Candida genus, with 4 or more episodes during the year were analyzed. For comparison, indices of 40 healthy women were analyzed too. Vaginal secretion was used as a study material. The analysis of local factors of the congenital immunity included the following: phagocytic activity, intracellular oxygen-dependent metabolism of neutrophilic granulocytes of the vaginal secretion, extracellular neutrophilic traps. Optical irradiation with low-level laser light was included into the treatment regimen starting from day one. Technical parameters of the applied laser therapy: wavelength 635 nm, power 5 mW, exposure 10 minutes, sessions 10.

Results. An imbalance of cellular factors of the congenital immunity detected before treatment: increased level of leukocytes, dysfunctions of the functional-metabolic status, decrease in the oxygen-dependent metabolism of neutrophilic granulocytes of the vaginal secretion. The revealed disorders in the local antimicrobial protection were eliminated with complex therapy which included low-level laser irradiation, wavelength 635 nm.

Conclusion. A local course therapy of the vulva and vagina with laser light having wavelength of 635 nm reliably reduces severity of objective and subjective symptoms of candidiasis, reduces the number of relapses forming more prolonged interrecurrent periods than after monotherapy.

The given paper presents results of the trial studying effects of intravenous laser blood irradiation (ILBI) at adiponectin and leptin dynamics in patients with metabolic syndrome (MS). 154 patients with MS (mean age 36,5 ± 3,6 years) were examined and treated. All patients were randomly divided into 2 groups: control (32 patients) and main (122 patients). Patients in the control group were treated according to MS treatment standards: lipid-lowering therapy, hypoglycemic agents, antihypertensive therapy. Patients from the main group had a course of intravenous laser therapy according to ILBI-405 technique instructions in combination with medicamentous therapy. Laser device «Matrix – VLOK» (Matrix Ltd, Russia) with wavelength 0,405 μm, output power at the end of main fiber tip 1–1.5 mW was used. ILBI session lasted for 15 minutes in a continuous mode; treatment course consisted of 10 daily sessions except weekends. Adiponectin and leptin levels were determined using the enzyme immunoassay set manufactured by BioVendor as well as with enzyme immunoassay and enzyme immunoassay analyzer Victor (PerkinElmer Ltd) with wavelength 450 nm. As it has been shown, ILBI included into comprehensive therapy normalizes adiponectin and leptin parameters.

Purpose: To optimize the technique of multomodal anesthesia using laser contact exposure with wavelength 650 nm at the projection of large vessels.

Materials and methods. 107 patients (68 women and 39 men) aged 50–94 with abdominal pathology and concomitant health problems were taken into the study. All patients were divided into two groups (studied – 76 patients and control – 31 patient). Multimodal anesthesia was potentiated in the studied group with additional sessions of quantum hemotherapy using semiconductor laser device «LASPOT» (China) of the fifth generation which has red irradiation range 650 nm, power 40mW. This device looks like a wrist watch, and is used for contact laser irradiation of the projection of large vessels and irradiation of nasal mucous where the minute blood flow passes during 3 min. In the control group, multimodal anesthesia was done without laser light potentiating.

Results. The described potentiating with optic irradiation in the studied group allowed to decrease the loading of narcotic analgesic Phentanil by three times, in average, during general anesthesia as well as to stabilize hemodynamic indexes, to increase the cardiac index and to decrease peripheral vascular resistance in operated patients.

Conclusion. The technique of multimodal anesthesia with optic irradiation can be recommended for wide application in clinical practice.

The aim of the present work was to study effects of intravenous laser blood irradiation (ILBI) at some indexes of plasma hemostasis and at the activity of rheumatoid arthritis.

Materials and methods. 130 people with confirmed rheumatoid arthritis were taken into the study. Patients in the control group (n = 30) received conventional medical therapy with basic anti-inflammatory drugs; patients in the main group (n = 100) had a course of intravenous laser therapy (ILBI) in addition to standard treatment. ILBI sessions were performed using laser device “Matrix-VLOK» (Matrix Ltd., Russia). Two laser heads were used for this therapy alternatively (every other day): KL-VLOK with wavelength 635 nm, output power at the end of the disposable fiber tip 1.5–2.0 mW, exposure 15 minutes and KL-VLOK 365 for UVBI with wavelength 365 nm, exposure 5 min. Daily sessions lasted for 10 days. Patients’ examination included analyses of activated partial thromboplastin time (APTT), prothrombin time (PTV), thrombin time (TV test), activity of protein C system as well as antithrombin III. Therapy dynamics and effectiveness were assessed with DAS28 index.

Results. It has been shown that ILBI sessions added to RA complex therapy significantly reduce disease activity and improve hemorheologic parameters.

The dominant complication of rigid stabilization of the lumbar spine is the syndrome of the disease of adjacent level (SDAL), one of the common causes of which is the facet syndrome (FS). Treatment of an isolated FS in SDAL is currently a poorly understood problem. The aim of the study was to analyze clinical efficacy of laser denervation of facet joints (FJ) of the lumbar spine with SDAL non-compressive forms after dorsal decompressive-stabilizing interventions. 354 patients were taken into the study after rigid stabilization who developed SDAL at different terms in the form of isolated FS and who had minimally invasive treatment – FJ laser denervation. Patients were divided into two groups: in Group I patients (n = 139) previously had one-segment decompressive-stabilizing surgery; in Group II patients (n = 215) had two-segment surgery. Anthropometric indexes (sex, age, body mass), clinical parameters (visual-analogue pain syndrome (VAS), Oswestry (ODI) functional status, Macnab subjective outcome scale), neuroimaging data (magnetic resonance imaging) were analyzed in both groups. Clinical outcomes after treatment were assessed in the minimal follow-up period – 36 months. As a result, it has been established that FJ laser denervation in patients with SDAL non-compressed forms after dorsal decompression-stabilizing interventions promotes good clinical outcomes as to pain syndrome and functional status. It also leads to minimal risks of perioperative adverse effects.

In the present work it has been shown that long single pulses and a series of short pulses with the same exposure duration and total energy density heat the dermal papilla and the bulge area differently. A series of short pulses produces more heat in the papilla what makes temporal hair removal more efficient. Exposure to long single impulses causes a more pronounced heating of the bulge area what provides better long-term effectiveness of epilation.

Purpose. To develop an algorithm for selecting optimal parameters of diode laser irradiation so as to achieve the required temperature level for thermal destruction of the dermal papilla and the bulge area during epilation with long pulses and a series of short pulses.

Material and methods. Epilation with long pulses was performed in 109 patients aged 20–80 having thick black and dark brown hair. The researchers took into account the depth of hair follicle location, Fitzpatrick skin phototype, patient’s age. Epilation was performed with Capello diode laser (wavelength 808 nm) manufactured by Promoitalia Ltd. (Italy). Parameters of energy density and pulse duration for hair removal were selected using the developed tables to determine the heating intensity of dermal papilla of black hair with its depth of 3.5–4.5 mm (fair skin). Pulse duration was 60–150 ms, energy density was 60–120 J /cm².

Results. After 7–9 sessions of thick black hair removal on the shin, thigh, armpits, chin, shoulder and forearm as well as on the pubic area, control examination in half a year and in one year detected only isolated hairs (not more than 1%) in all treated zones.

Conclusion. The developed tables can be used to determine optimal parameters (exposure duration and energy density) for a single impulse in order to achieve necessary temperature level to get thermal destruction of both dermal papilla and bulge area in patients with thick black hair and depth of 3.5–4.5 mm.

The aim of the study is to evaluate results of subdermal-submucous laser destruction of internal hemorrhoids in out-patient settings for the treatment of patients with chronic internal hemorrhoids of degrees II and III.

Material and methods. Subdermal-submucous laser destruction of internal hemorrhoids was performed in 14 patients with chronic internal hemorrhoids of degrees II and III: 2 females and 12 males. Average age 41.42 ± 13 years. Disease duration 10 ± 9.5 years. Surgery was performed under local infiltration anesthesia with 0.25% solution of lidocaine hydrochloride. Diode laser device Mediola Compact (Republic of Belarus) was used for the procedure.

Results. Surgery lasted for 20.27 ± 5 min. There were no any intraoperative complications. Pain syndrome after surgery was 1–2 points by the 10-point scale. One patient (10%) developed thrombosis of internal hemorrhoids after surgery which was stopped by conservative measures on day 10. The remaining 13 patients resumes their active work on day 5. At the follow-up visit one month after the surgery, patients had no complaints. On examination, hemorrhoidal nodes did not move; their size became less and they did not fall out when straining for defecation.

Conclusion. The described technique for subdermal-submucous laser destruction of internal hemorrhoidal nodes is effective and safe for treating patients with chronic internal hemorrhoids of stages II and III in out-patient settings.

Using the laser Doppler method (LDF), the degree of variability of blood microcirculation and microvascular reactivity in the foot was studied in 40 young people with varying degrees of flatfoot. In order to identify the reactivity of microvessels in foot, the microcirculation indicators were recorded at rest (at lying position) and during the postural test (with the leg hanging down). It has been established that in individuals with an average height of the foot arch, the microcirculation intensity and the microvascular reactivity of the foot skin are balanced under load. In the case of a high-arched foot, there is an increase in blood perfusion of tissues and a tendency to an increased activity of microcirculation regulatory mechanisms. With the depletion of the myogenic mechanism of regulation of microcirculation, the activity of the neurogenic mechanism was identified increasing. In the case of low-arched foot and flatfoot, there is a decrease in blood flow in the microvessels of the sole. This may be due to a decrease in intravascular resistance and an increase in the myogenic tone of microvessels. In individuals with flatfoot, the microvascular reactivity in the sole of the foot significantly decreases. The decrease in microvascular reactivity in flatfoot reduces the ability of its adaptation to different functional conditions.

Purpose: To develop a new technique for surgical treatment of purulent peritonitis.

Material and methods. 100 Wistar rats were divided into 3 groups and were operated on. Peritonitis was modulated and then, on day 2, enteric anastomosis was formed at 90° and 60° angles of intestinal resection. On day 7, the animals were taken out of the experiment. Laser photodynamic therapy (PDT) was applied to the formed anastomosis using semiconductor laser Lakhta Milon with wavelength 662 nm and output power 200 mW. The targeted area was irradiated with a distant mono position mode to achieve light dose density equal to 20–25 J/cm². 0.3% methylene blue solution was used as a photosensitizer. Postoperative mortality, number of inconsistent anastomoses and abdominal abscesses were compared in the groups. The researchers also investigated blood and lymphatic vessels in the intestinal wall, level of neutrophilic leukocytes, lymphocytes and fibroblasts along the line of intestinal suture.

Results. As it has been found out, the number of inconsistent anastomoses and abdominal abscesses as well the mortality rate were the smallest in the group of animals in which anastomoses were made at 60° angle and then treated with photodynamic sessions. It was also noted that photodynamic therapy decreased the intensity of local inflammatory response in the intestinal wall.

Conclusion. The developed technique for intestinal anastomosis formation with the resection of both intestinal loops at the angle of 60° and the subsequent photodynamic treatment of anastomoses reduces the risk of their failure and abdominal abscesses.