Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer
https://doi.org/10.37895/2071-8004-2023-27-2-8-15
Abstract
Purpose. To study outcomes after the combined treatment of locally advanced colon cancer with intraoperative photodynamic therapy.
Materials and methods. 35 patients with locally advanced colon cancer were included in the trial. Patients from the main group (n = 17) had intraoperative photodynamic therapy in combination with elective surgery. Patients from the control group (n = 18) had only surgical treatment. For photodynamic therapy, photosensitizer Photolon and “Lakhta-Milon” diode laser with wavelength 662 nm and power up to 2.5 W were used. Laser light was delivered via a quartz polymer fiber with diameter 600 microns.
Results and discussion. Better positive immediate and long-term outcomes were registered in patients with locally advanced colon cancer from the main group, if to compare with the control group (length of hospital stay, number of remissions, relapses and mortality).
Conclusion: Intraoperative photodynamic therapy improves outcomes after the combined treatment of patients with locally advanced colon cancer.
About the Authors
I. V. Krochek
South-Ural State Medical University; City Clinical Hospital No 1
Russian Federation
Russian Federation
Igor Krochek, MD., Dr. Sci. (Med.), Professor
department of general and pediatric surgery
Chelyabinsk
R. D. Ibatullin
City Clinical Hospital No 1
Russian Federation
Russian Federation
Robert Ibatullin, MD., head of department
oncologic department
Chelyabinsk
A. V. Lappa
Chelyabinsk State University
Russian Federation
Russian Federation
Alexander Lappa, Dr. Sci. (Phys. and Math.), Professor
department of general and theoretical physics
Chelyabinsk
A. E. Anchugova
South-Ural State Medical University; Chelyabinsk State University
Russian Federation
Russian Federation
Anastasia Anchugova, physicist, senior lecturer
Scientific and Educational Center “Problems of Fundamental Medicine”
department of general and theoretical physics
Chelyabinsk
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Review
For citations:
Krochek I.V., Ibatullin R.D., Lappa A.V., Anchugova A.E. Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer. Laser Medicine. 2023;27(2):8-15. (In Russ.) https://doi.org/10.37895/2071-8004-2023-27-2-8-15
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