Combinational antimicrobial photodynamic therapy of chronic tonsillitis

Abstract

43 patients suffering of various forms of chronic tonsillitis (CT) were treated with a combined antimicrobial photodynamic therapy (CA PDT). Microbiological studies performed before on the culture taken from the tonsil mucous of the studied patients revealed a high level of film formation activity. During the experimental work the researchers studied effects of enzymes (trypsin, lidasa, ribonuclease) at matured bacterial biofilms which consisted of monocultures and their associations. Results of the experimental work and the obtained microbiological findings have shown that lidasa turned to be the most effective enzyme. So, this enzyme was chosen for application in clinical practice. All patients were divided into three groups: patients from Group 1 (n = 13) received a conventional conservative therapy (lavage of tonsil lacunas, antibiotic therapy, physiotherapy, etc.); patients from Group 2 (n = 16) had CA PDT with preliminary treatment of tonsils with lidasa; patients from Group 3 (n = 14) also had CA PDT with preliminary treatment of tonsils with lidasa plus subsequent probiotic therapy. This study has shown that the combination of enzymes, probiotics and CA PDT increases the effectiveness of treatment and prolongs remission without any adverse and unwanted allergic reactions.