Clinical and immunological efficacy of local use of low-level laser radiation with wavelength 635 nm for treating infectious diseases of the genitourinary system
https://doi.org/10.37895/2071-8004-2019-23-1-6-12
Abstract
Objective: To evaluate the effectiveness of local low-level laser irradiation with wavelength 635 nm in the complex therapy of candidal lesions of mucous membranes in the urogenital system.
Material and methods. Clinical picture, factors of the congenital immunity in 100 women with verified diagnosis of inflammatory disease caused by yeast-like fungi of the Candida genus, with 4 or more episodes during the year were analyzed. For comparison, indices of 40 healthy women were analyzed too. Vaginal secretion was used as a study material. The analysis of local factors of the congenital immunity included the following: phagocytic activity, intracellular oxygen-dependent metabolism of neutrophilic granulocytes of the vaginal secretion, extracellular neutrophilic traps. Optical irradiation with low-level laser light was included into the treatment regimen starting from day one. Technical parameters of the applied laser therapy: wavelength 635 nm, power 5 mW, exposure 10 minutes, sessions 10.
Results. An imbalance of cellular factors of the congenital immunity detected before treatment: increased level of leukocytes, dysfunctions of the functional-metabolic status, decrease in the oxygen-dependent metabolism of neutrophilic granulocytes of the vaginal secretion. The revealed disorders in the local antimicrobial protection were eliminated with complex therapy which included low-level laser irradiation, wavelength 635 nm.
Conclusion. A local course therapy of the vulva and vagina with laser light having wavelength of 635 nm reliably reduces severity of objective and subjective symptoms of candidiasis, reduces the number of relapses forming more prolonged interrecurrent periods than after monotherapy.
About the Authors
O. A. Gizinger
South Ural State Medical University
Russian Federation
Chelyabinsk
Russian Federation
Chelyabinsk
V. I. Karandashov
Skobelkin State Scientific Center of Laser Medicine
Russian Federation
Moscow
Russian Federation
Moscow
O. R. Ziganshin
South Ural State Medical University
Russian Federation
Chelyabinsk
Russian Federation
Chelyabinsk
I. V. Semenova
Chelyabinsk Regional Dermatovenerologic Dispensary
Russian Federation
Chelyabinsk
Russian Federation
Chelyabinsk
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Review
For citations:
Gizinger O.A., Karandashov V.I., Ziganshin O.R., Semenova I.V. Clinical and immunological efficacy of local use of low-level laser radiation with wavelength 635 nm for treating infectious diseases of the genitourinary system. Laser Medicine. 2019;23(1):6-12. (In Russ.) https://doi.org/10.37895/2071-8004-2019-23-1-6-12
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