Antibacterial photodynamic therapy of purulent wounds in soft tissues

Abstract

Purpose. To optimize treatment of patients with purulent wounds in soft tissues of various genesis using laser photodynamic therapy (PDT). Material and methods. The authors have analyzed results of complex examination and management of 125 patients with purulent wounds in soft tissues of various genesis. In the control group, patients had traditional topical therapy of wounds with antiseptics of various physical forms depending on the phase of wound process. Patients from the studied group has laser PDT with microcupsulated 0.1% Photoditazine preparation complexed with amphiphilic polymers and hydroxyapatite in a gel form. The researchers studied the dynamics of wound process depending of the process phase. Results. PDT of purulent wounds using Photoditazine complexed with amphiphilic polymers and hydroxyapatite in gel and microcupsulated forms causes marked activation of processes purifying wound of necrotized tissues, fibrin and microorganism colonies in the zone of primary wound canal. Conclusion. Photodynamic therapy of purulent wounds in soft tissues with Photoditazine complexed with amphiphilic polymers and hydroxyapatite in gel and microcupsulated forms is highly effective, and far exceeds traditional techniques as it has been proven by clinical, cytological, histological and bacteriologic examinations.