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Assessment of the liver functional state in a patient with obstructive jaundice associated with the Klatskin tumor (Clinical observation)

https://doi.org/10.37895/2071-8004-2024-28-4-42-50

Abstract

One of the diseases of the biliary area accompanied with the obstructive jaundice syndrome is a portal cholangiocarcinoma or the Klatskin tumor. The authors assess the liver functional state in a patient with portal cholangiocarcinoma using the wedge-shaped dehydration. After diagnosing the Klatskin tumor type III by the Bismuth-Corlette scale and obstructive jaundice, the patient underwent separate external percutaneous transhepatic cholangiostomy of the right and left hepatic ducts under ultrasound and X-ray control. While making the primary percutaneous access to the biliary tract, and every three days after, the researchers studied crystallographic properties of the bile from the right and left liver lobes using the wedge-shaped dehydration method. This examination showed that the left lobe of the liver had more severe dysfunction disorders than the right one. The obtained information, laboratory and instrumental fi ndings were used to choose further management tactics and surgical modality in the described patient. The presented clinical case demonstrates the effectiveness of wedge-shaped dehydration in the dynamic assessment of liver metabolism and a possible effective application of the discussed technique in the management algorithm of patients with obstructive jaundice associated with a portal cholangiocarcinoma.

About the Authors

D. S. Sumin
Orel Regional Clinical Hospital; Orel State University
Russian Federation

Dmitriy S. Sumin – surgeon of the department of surgical X-ray diagnostic and management techniques

Orel



A. V. Mamoshin
Orel State University; National Medical Research Center of Surgery named after A.V. Vishnevsky
Russian Federation

Andrian V. Mamoshin – Dr. Sci. (Med.), Associate Professor, senior researcher at the department of abdominal surgery; Professor of the department of specialized surgical disciplines, Medical Institute; senior researcher at Research and Development Center of Biomedical Photonics

Orel



K. Yu. Kandurova
Orel State University
Russian Federation

Ksenia Yu. Kandurova – postgraduate student at the Department of Instrumentation, Metrology and Certifi cation; intern researcher at the Research and Development Center of Biomedical Photonics 

Orel 



V. N. Prizemin
Orel State University
Russian Federation

Vadim N. Prizemin – laboratory assistant at the laboratory of Cellular Physiology and Pathology 

Orel



A. V. Dunaev
Orel State University
Russian Federation

Andrey V. Dunaev – Dr. Sci. (Tech.), leading researcher at the Research and Development Center of Biomedical Photonics; Professor at the Instrumentation, Metrology and Certification Department

Orel



E. V. Potapova
Orel State University
Russian Federation

Elena V. Potapova – Cand. Sci. (Tech.), senior researcher at the Research and Development Center of Biomedical Photonics; Associate Professor of Instrumentation, Metrology and Certification Department

Orel



References

1. Romashchenko P.N., Maistrenko N.A., Kuznetsov A.I., Pryadko A.S., Filin A.A., Aliev A.K., Zherebtsov E.S. Malignant obstructive jaundice: justifi cation of the method of biliary decompression. Annals of HPB Surgery. 2020; 25 (2): 124–136. (In Russ.). DOI: 10.16931/1995-5464.20202124-136

2. Duberman B.L., Mizgirev D.V., Epshtein A.M., Pozdeev V.N., Tarabukin A.V. Malignant obstructive jaundice: approaches to minimally invasive biliary decompression. Annals of HPB Surgery. 2019; 24 (2): 36–47. (In Russ.). DOI: 10.16931/19955464.2019236-47

3. Modern surgical treatment of elderly patients with choledocholithiasis and obstructive jaundice / M.M. Vinokurov, A.P. Petrov, V.V. Savelyev. Yakut Medical Journal. 2022; 1 (77): 35–38. (In Russ.). DOI: 10.25789/YMJ.2022.77.09

4. Prognostic effects of different malignant obstructive jaundice sites on percutaneous biliary intervention: A retrospective controlled study / J. Xu, S. Zhuang, M. Liu [et al.]. Journal of cancer research and therapeutics. 2023; 19 (1): 78–85. DOI: 10.4103/jcrt.jcrt_2038_22

5. Podoluzhnyi V.I. Obstructive jaundice: current principles of diagnosis and treatment. Fundamental and Clinical Medicine. 2018; 3 (2): 82–92. (In Russ.). DOI 10.23946/2500-07642018-3-2-82-92

6. Galperin E.I. Guide to surgery of the biliary tract. 2nd ed. Edited by E.I. Galperin, P.S. Vetshev, M. Vidar M.. 2009; 568. (In Russ.).

7. Balogun O.S. Management of Malignant Obstructive Jaundice: Defi ning the Relevance of Various Palliative Surgical Options in Resource-Challenged Settings: A Review Article / O.S. Balogun, O.A. Atoyebi. Journal of the West African College of Surgeons. 2024; 1 (3): 111–119. DOI: 10.4103/jwas. jwas_22_22

8. Fekaj E. Obstructive Jaundice / E. Fekaj, N. Jankulovski, N. Matveeva. Austin Dig Syst. 2017; 2 (1): 1006.

9. Pel’ts V.A., Tropin V.E., Pachgin I.V. 2023. The Operation of Laparoscopic Isolation of the Portal Blood Flow as a Method for the Prevention of Post-Resection Liver Failure. Challenges in Modern Medicine. 2023; 46 (2): 203–214 (In Russ.). DOI: 10.52575/2687-0940-2023-46-2-203-214

10. The effect of bile absorption on the main factors of endogenous intoxication in patients with obstructive jaundice / N.U. Arkhipova, S.I. Jamalov, J.K. Babajanov [et al.]. Journal of Theoretical and Clinical Medicine. 2022; 1: 36–42. (In Russ.).

11. EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure / J. Wendon, J. Córdoba, A. Dhawan, [et al.]. J. Hepatol. 2017; 66 (5): 1047–1081. DOI: 10.1016/j.jhep.2016.12.003

12. Alikhanov R.B. Post-resection liver failure. Prognosis, prevention and treatment : dis. ...Doctor of medical Sciences: 3.1.9/ Postresection liver failure. Prognosis, prevention and treatment : dissertation for the degree of Doctor of Medical Sciences: 3.1.9 / Ruslan Bogdanovich Alikhanov. Moscow, 2024: 208. (In Russ.).

13. Kabanov M.Yu., Sementsov K.V., Boyarinov D.Yu., Myanzelin M.N., Belikova M.Ya., Alekseev V.V. Diffi culties in assessing the severity of liver dysfunction for obstructive jaundice. Annals of HPB Surgery. 2021; 26 (2):129–136. (In Russ.). DOI: 10.16931/10.16931/1995-5464.2021-2-129-136

14. Modern surgical treatment of elderly patients with choledocholithiasis and obstructive jaundice / M.M. Vinokurov, A.P. Petrov, V.V. Savelyev. Yakut Medical Journal. 2022; 1 (77): 35–38. (In Russ.). DOI: 10.25789/YMJ.2022.77.09

15. Current concepts in acute liver failure / M. Rovegno, M. Vera, A. Ruiz, C. Benítez. Ann. Hepatol. 2019; 18 (4): 543–552. DOI: 10.1016/j.aohep.2019.04.008

16. Effect of percutaneous biliary drainage on enzyme activity of serum matrix metalloproteinase-9 in patients with malignant hilar obstructive hyperbilirubinemia / A. Filipović, D. Mašulović, K. Gopčević [et al.]. Medicina (Kaunas, Lithuania). 2023; 59 (2): 336. DOI: 10.3390/medicina59020336

17. Selection of the level of intersection of the pancreas, taking into account the topography of arterial vessels and pancreatic duct / S.V. Tarasenko, P.V. Tarakanov, A.A. Natalsky [et al.]. Surgical News. 2021; 29 (2): 175–182. (In Russ.). DOI: 10.18484/2305-0047.2021.2.175

18. Hanif F. Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard / H. Hanif, S.A. Khan, S. Muneer, S.O. Adil. Pakistan journal of medical sciences. 2020; 36 (4): 652–656. DOI: 10.12669/ pjms.36.4.1665

19. Takada T. Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis / T. Takada. Journal of hepato-biliary-pancreatic sciences. 2018; 25 (1): 1–2. DOI: 10.1002/jhbp.526

20. Ali M. Percutaneous trans-hepatic biliary drainage: A retrospective study from a tertiary care hospital in Pakistan / M. Ali, A. Sulaiman, O. Parkash. The Journal of the Pakistan Medical Association. 2022; 72 (10): 2084–2085. DOI: 10.47391/JPMA.4283

21. Denning A.G. Preoperative percutaneous transhepatic biliary decompression lowers operative morbidity in patients with obstructive jaundice / D.A. Denning, L.C. Carey. Am. J. Surg. Elsevier. 2018; 221 (6): 68–74. DOI: 10.1016/0002-9610(81)90013-1

22. Banales J.M. Cholangiocarcinoma 2020: the next horizon in mechanisms and management / J.M. Banalts, J.G. Marin, A. Lamarca [at al.]. Nat Rev Gastroenterol Hepatol. 2020; 17 (9): 557–588. DOI: 10.1038/s41575-020-0310-z

23. Maady A.S. Minimally invasive technologies for drainage of the biliary tract in unresectable tumors of the hepatopancreatobiliary zone complicated by obstructive jaundice: dis. ... Doctor of Medical Sciences: 01/14/17 / Ayas Sergeevich Maady. Moscow, 2015. 264 p. (In Russ.).

24. Gal’perin ÉI, Kotovskiĭ AE, Momunova ON. Rate of biliary ducts’ decompression by the tumorous obstructive jaundice. Pirogov Russian Journal of Surgery. 2011; (8): 33–40. (In Russ.).

25. Chereshnev N.A. New approaches to the diagnosis of liver failure in surgical pathology of the biliary tract and pancreas / V.A. Chereshnev, N.A. Zubareva, D.Yu. Sosnin. Bulletin of the Ural Medical Academic Science. 2011; 1: 67–70. (In Russ.).

26. Y.S. Vinnik, S.S. Dunaevkaya, A.A. Kosik, R.Y. Hlobystin. Risk assessment of post-sectional liver failure / Far Eastern Medical Journal. 2021; 2: 33–36. (In Russ.). DOI: 10.35177/1994-5191-2021-2-33-36

27. Optimization of liver failure treatment in patients with obstructive jaundice / K.R. Ruziboyzoda, M.K. Gulov, A.M. Safarzoda [et al.]. Bulletin of the National Medical and Surgical Center named after N.I. Pirogov. 2023; 18 (1): 69–73. (In Russ.). DOI: 10.25881/20728255_2023_18_3_66

28. The impact of preoperative biliary drainage on postoperative outcomes in patients with malignant obstructive jaundice: a retrospective analysis of 290 consecutive cases at a single medical center / Z. Gao, J. Wang, S. Shen [et al.]. World journal of surgical oncology. 2022; 20 (1): 7. DOI: 10.1186/ s12957-021-02476-z

29. Poltavsky D.I.; Kuchurina V.A.; Bekezin V.V. Features of Blood Hydration Processes (Crystallography Method) in Individuals with Various Somatic Pathologies (Review). Smolenskiy Meditsinskiy Almanakh. 2024; 2: 124–126. (In Russ.).

30. Vahrushev Ya.M., Hochlacheva N.A., Glazyrina N.N., Farrakhov A.M. Diagnosis of promicrolithic changes in gallbladder bile by crystallography. Experimental and Clinical Gastroenterology. 2021; 1 (5): 12–18. (In Russ.). DOI: 10.31146/1682-8658-ecg-189-5-12-18

31. Kidalov V.N. Tesiography of Blood and Biological Fluids / V.N. Kidalov, A.A. Khadartsev. Tula: Tula Polygraphist, 2009, p. 244. (In Russ.).

32. Thermographic method of blood plasma examination by A.O. Buglak, V.G. Shestakova, E.B. Ganina et al.. Tver Medical Journal. 2023; 5: 67-71. (In Russ.).

33. Vakhrushev Ya.M., Khokhlacheva N.A., Moseeva M.V., Glazyrina N.N., Bystrova A.V. The importance of the morphometric research of bile in early diagnostics of bilious stone formation. The Russian Archives of Internal Medicine. 2018; 8 (6): 458–463. (In Russ.). DOI: 10.20514/2226-6704-2018-8-6-458-463

34. Patent No. RU 2826265, issued on September 9, 2024, to Orel State University, is a method for assessing the severity of liver failure in patients with obstructive jaundice syndrome. The patent was fi led on April 4, 2023, and has the following IPC codes: G01N 33/48, G01N 33/487, and G01N 1/40. (In Russ.).

35. Shatalov R.P. Differential diagnosis and therapeutic tactics for fl uid formations complicating the course of acute destructive pancreatitis: dis. ... Candidate of Medical Sciences: 01/14/17 / Shatalov Roman Petrovich. Kursk, 2017. 168 p. (In Russ.).


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For citations:


Sumin D.S., Mamoshin A.V., Kandurova K.Yu., Prizemin V.N., Dunaev A.V., Potapova E.V. Assessment of the liver functional state in a patient with obstructive jaundice associated with the Klatskin tumor (Clinical observation). Laser Medicine. 2024;28(4):42-50. (In Russ.) https://doi.org/10.37895/2071-8004-2024-28-4-42-50

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