Selective application of laser light with wavelength 1268 μm for treating solid tumours. Physical methods for potentiating the immune response
https://doi.org/10.37895/2071-8004-2016-20-2-62-65
Abstract
During the experimentation with melanoma В16 it has been shown that laser light at X = 1268 μm has a highly selective effect at solid tumours. Such a phenomenon may be explained by physical-chemical processes involved in the immune system response to antigen and comprises the generation of lacking components usually produced by the immune system, singlet oxygen in particular. Other opportunities of potentiating the immune system are also discussed.
References
1. Амбарцумян Р.В., Богуш Т.А., Елисеенко В.И. Подавление опухолевого роста лазерными импульсами высокой интенсивности. Прямое фотовозбуждение молекулярного кислорода в состояние 1Δg // Лазерная медицина. - 2014. - Т. 18. - Вып. 1. -C. 25-30.
2. Девятков Н.Д., Плетнев С.Д., Чернов З.С. и др. Воздействие низкоэнергетического импульсного КВЧ и СВЧ-излучения наносекундной длительности с большой пиковой мощностью на биологические структуры (злокачественные образования) // ДАН. - 1994. - 336. - C. 826-828.
3. Ambartzumian R.V. Lasers in Cardiology // In 1986 European Conference on Optics, Optical Systems and Applications, S. Sottini and S. Trigary Editors, Proc. - SPIE, 1987. - V. 701. -P. 341-343.
4. Ambartzumian R.V, Arutunian A.A., Voskanian K.Sh., Melkonian A.A. Cytotoxic Effect of Laser Irradiation at 1.27 Microns // In Laser Application in Medicine and Surgery, ed. Galetty G., Bolognany L., Ussia G., Monduzzi Edito. - Bologna, 1992. -P. 247-251.
5. Investigation 3 of nonthermal destruction of malignant tumors by laser radiation at different wavelengths. Final Technical Report of ISTC 1552 // Aug. 2003. http: //www.istc.ru/istc/db/projects.nsf'All/582457BAFE4B1ACE4325691E007063F2?0penDocument&search=1
6. Hanahan D. Weinberg R.A. Hallmarks of cancer: the next generation // Cell. - 2011. - 144. - P. 46-674.
7. Kettle 12A.J., Clark B.M., Winterbourn C.C. Superoxide converts indigo carmine to isatin sulfonic acid // The J. Biol. Chem. - 2004. -279. - № 18. - Issue of April 30. - P. 18521-18525.
8. Leunig A., Staub F., Peters J. et al. Volume changes of A-Mel3 tumor cells induced by photodynamic treatment // In Photodynamic Therapy and Biomedical Lasers; Proceedings of International Conf. on Photodynamic Therapy and Medical Laser Applications; Milan, 24-27 June 1992, editors P. Spinelli, M. Dal Fante, R. Marche-sini. - Amsterdam-London-N-Y-Tokyo: EXCERPTA-MEDICA, 1992. - P. 751-754.
9. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes // Trends Immunol. -2002. - 23 (11). - P. 549-555.
10. Schreiber R.D., Old L.J., Smyth M.J. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion // Science. - 2011. - 331. - P. 1565-1570.
11. Wentworth A.D., Jones L.H., Wentworth P. et al. Antibodies have the intrinsic capacity to destroy antigens // PNAS. - 2000. - 97. -P. 10930-10935.
12. Wentworth P.J., Wentworth A.D., Xueyong Zhu et al. Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigen // PNAS. - 2003. - V. 100. -P. 1490-1493.
13. Van Vleck J.H. The absorption of microwaves by oxygen // Physical Review. - 1947. - V. 7. - P. 413-424.
14. Zhuravkin I.N., Kostenich G.A. and Zavrid E.A. Photodynamic activity of chlorin e6 in experiment // In Photodynamic Therapy and Biomedical Lasers; Proceedings of International Conf. on Photodynamic Therapy and Medical Laser Applications; Milan, 24-27 June 1992 / Editors P. Spinelli, M. Dal Fante, R. Marche-sini. - Amsterdam-London-N-Y-Tokyo: EXCERPTA-MEDICA, 1992. - P. 535-538.
Review
For citations:
Ambartzumian R.V. Selective application of laser light with wavelength 1268 μm for treating solid tumours. Physical methods for potentiating the immune response. Laser Medicine. 2016;20(2):62-65. (In Russ.) https://doi.org/10.37895/2071-8004-2016-20-2-62-65
Views:
156
Email this article 