Photodynamic activity of water dispersion of gold nanoparticles for treating experimental purulent wounds
T. A. Shulgina,
E. F. Stranadko,
O. V. Nechaeva,
E. V. Glinskaya,
K. V. Zubova,
D. A. Schnaider,
N. V. Bespalova https://doi.org/10.37895/2071-8004-2021-25-4-35-41
Abstract
Introduction. Antimicrobial photodynamic therapy is one of the highly effective techniques for treating infectious lesions of the skin and soft tissues. However, the search for safe photosensitizers remains relevant.
Purpose: to study the application of aqueous dispersion of gold nanoparticles as a potential photosensitizer for antimicrobial photodynamic therapy in experimental purulent wounds.
Material and methods. Photosensitizing ability of aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol was studied on experimental full-thickness purulent wounds in rats. Semiconductor laser (Alcom Medica, St. Petersburg) with wavelength 405 nm was used.
Results. It has been found out that pretreatment of wounds with nanostructures followed by photodynamic exposure gives a 1.6-fold reduction of healing process of wound defects in laboratory animals compared to the control group. in experimental animals, an effective cleansing of wounds from purulent contents was observed as well.
Conclusion. An aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol can be considered as an effective photosensitizer for antimicrobial photodynamic therapy.
About the Authors
T. A. Shulgina
Scientifi c Research Institute of Traumatology, Orthopedics and Neurosurgery of the Saratov State Medical University named after
V.I. Razumovsky
Russian Federation
Russian Federation
Shulgina Tatiana – Biologist, Scientifi c Research Institute of Traumatology, Orthopedics and Neurosurgery
Saratov
E. F. Stranadko
Skobelkin State Scientifi c Center of Laser Medicine FMBA of Russia
Russian Federation
Russian Federation
Stranadko Evgeniy – Dr. Sc. (Med.), Professor, the Head of the Department of Laser Oncology and Photodynamic Therapy, Scientific Research Institute of Traumatology
Moscow
O. V. Nechaeva
Yuri Gagarin State Technical University; Saratov Regional Clinical Dermatovenerologic Dispensary
Russian Federation
Russian Federation
Nechaeva Olga – Professor, Dr. Sc. (Biol.), Professor of the Department of Ecology and Technosphere Safety; Biologist at the
Bacteriological Laboratory
Saratov
E. V. Glinskaya
Saratov State University
Russian Federation
Russian Federation
Glinskaya Elena – Cand. Sc. (Biol.), Assistant Professor at the Department of Plant Microbiology and Physiology
Saratov
K. V. Zubova
Saratov State University
Russian Federation
Russian Federation
Zubova Kseniya – Postgraduate at the Department of Plant Microbiology and Physiology
Saratov
D. A. Schnaider
Saratov Regional Clinical Dermatovenerologic Dispensary
Russian Federation
Russian Federation
Schnaider Dmitry – Chief Physician
Saratov
N. V. Bespalova
Yuri Gagarin State Technical University
Russian Federation
Russian Federation
Bespalova Natalya – Cand. Sc. (Phys.), Assistant Professor at the Department of Information Security of Automated Systems
Saratov
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Review
For citations:
Shulgina T.A., Stranadko E.F., Nechaeva O.V., Glinskaya E.V., Zubova K.V., Schnaider D.A., Bespalova N.V. Photodynamic activity of water dispersion of gold nanoparticles for treating experimental purulent wounds. Laser Medicine. 2021;25(4):35-44. (In Russ.) https://doi.org/10.37895/2071-8004-2021-25-4-35-41
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