Preview

Laser Medicine

Advanced search

Laser treatment of chondromalacia lesions in the articular cartilage

https://doi.org/10.37895/2071-8004-2021-25-4-9-15

Abstract

Objective: to select optimal parameters of two-wave near-infrared laser irradiation for the arthroscopic treatment of chondromalacia foci  in the articular cartilage.  

Material and methods. Bull articular cartilages were treated with laser light delivered by a fifi ber and having various parameters. Human articular  cartilages with chondromalacia foci taken during the total knee replacement were also treated with laser light delivered by a fifi ber and having  various parameters. The processed cartilage samples were examined macroscopically and then histologically. Changes in the structure of ar[1] ticular cartilage after laser irradiation were assessed.  

Results. A two-second irradiation with two-wave laser light (λ = 0.97 μm / 30 W and λ = 1.55 μm / 15 W) causes a rapid “melting” of lesion margins  without macroscopically visible carbonization with a wide thermally affected zone in the irradiated area. Histologically, cartilage preparations  irradiated with two-wave laser light (wavelengths λ = 1.55 μm / 5 W and λ = 0.97 μm / 3 W) for 2 sec demonstrated slight changes in the cartilage  structure without thermal destruction of chondrocytes.

Conclusion. The optimal combination for laser irradiation of the cartilage tissue in the saline solution environment which restores articular cartilage  shape is two-wave laser light λ = 0.97 μm at power of 3 W and λ = 1.55 μm at power of 5 W from the distance of 1–2 mm under 2 sec exposure.   

About the Authors

A. V. Lychagin
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Lychagin Alexey – Dr. Sc. (Med.), Head of the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



S. V. Ivannikov
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Ivannikov Sergey – Dr. Sc. (Med.), Professor at the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



V. I. Yusupov
Institute of Photon Technologies of Federal Scientifi c Research Centre “Crystallography and Photonics” of Russian Academy of Science
Russian Federation

Yusupov Vladimir – Cand. Sc. (Tech.), Senior Researcher, Institute of Photon Technologies

Moscow



L. A. Semenova
Central Tuberculosis Research Institute
Russian Federation

Semenova Lyudmila – Cand. Sc. (Med.), Senior Researcher at the Department of Pathomorphology

Moscow



E. D. Startseva
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation

Startseva Yekaterina – Postgraduate at the Department of Laser Physics

Moscow



V. V. Surin
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Surin Vladimir – Postgraduate at the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



I. O. Tinkova
Botkin Hospital
Russian Federation

Tinkova Irina – Cand. Sc. (Med.), Pathologist

Moscow



A. I. Naimann
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Naimann Andrei – Cand. Sc. (Med.), Orthopedic Traumatologist

Moscow



T. A. Zharova
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Zharova Tatyana – Dr. Sc. (Med.), Associate Professor at the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



P. A. Przhevalsky
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Przhevalskii Pavel – Postgraduate at the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



Y. Yan
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation

Yang Yanbin – Postgraduate at the Department of Traumatology, Orthopaedics and Disaster Surgery

Moscow



References

1. Zhulikov A.L., Malanin D.A., Novochadov V.V., Goryachev A.N. Morphological and morphometric results of noncontact exposure of cold plasma to articular cartilage in the experiment . Volgograd Journal of Medical Research. 2010; 2 (26): 32–36. [In Russ.].

2. Bogatov V.B., Matveeva O.V., Petrov A.B. Effect of cold plasma ablation at human and experimental animal knee cartilage. Traumatology and Orthopedics of Russia. 2011; 1 (59): 61–66. [In Russ.].

3. Ivannikov S.V. Laser arthroscopic surgery: Degenerativedystrophic lesions of the knee joint: Dissertation of Dr. Sc. (Med.). Moscow; 2001. [In Russ.].

4. Sandler B.I., Sulyandziga L.N., Chudnovskiy V.M., et al. Prospects for the treatment of discogenic compression forms of lumbosacral radiculitis using puncture non-endoscopic laser operations. Vladivostok: Dal’nauka; 2004. [In Russ.].

5. Bagratashvili V.N., Baskov A.V., Borshchenko I.A., et al. Laser engineering of cartilage. Moscow: Fizmatlit; 2006. [In Russ.].

6. Sobol E., Baskov A., Shekhter A., et al. Laser regeneration of spine discs cartilage: mechanisms, in-vivo study and clinical applications. Lecture notes in electrical engineering. 2008; 12 LNEE: 259–266. DOI: 10.1007/978-0-387-71809-5_24

7. Holden P.K., Li C., Da Costa V., et al. The effects of laser irradiation of cartilage on chondrocyte gene expression and the collagen matrix. Lasers Surg Med. 2009: 41 (7): 487–491. DOI: 10.1002/lsm.20795

8. Wong B.J.F., Pandhoh N., Truong M.T., et al. Identifi cation of chondrocyte proliferation following laser irradiation, thermal injury, and mechanical trauma. Lasers Surg Med. 2005; 37 (1): 89–96. DOI: 10.1002/lsm.20180

9. Yusupov V.I., Chudnovskii V.M., Bagratashvili V.N. Laserinduced hydrodynamics in water-saturated biotissues. 1. Generation of bubbles in liquids. Laser Phys. 2010; 20 (7): 1641–1646. DOI: 10.1134/S1054660X1014001X

10. Yusupov V.I., Chudnovskii V.M., Bagratashvili V.N. Laserinduced hydrodynamics in water-saturated biotissues. 2. Effect on delivery fi ber. Laser Phys. 2011; 21 (7): 1230–1234. DOI: 10.1134/S1054660X11140015

11. Yusupov V.I., Bulanov V.V., Chudnovskii V.M., Bagratashvili V.N. Laser-induced hydrodynamics in water-saturated tissue: III. Optoacoustic effects. Laser Phys. 2013; 24 (1): 015601. DOI: 10.1088/1054-660X/24/1/015601

12. Yusupov V.I., Konovalov A.N., Ul’yanov V.A., Bagratashvili V.N. Generation of acoustic waves by cw laser radiation at the tip of an optical fi ber in water. Acoust Phys. 2016; 62 (5): 537–544. DOI: 10.1134/S1063771016050183

13. O’Conor C.J., Case N., Guilak F. Mechanical regulation of chondrogenesis. Stem Cell Res Ther. 2013; 4 (4): 61. DOI: 10.1186/scrt211

14. Fahy N., Alini M., Stoddart M.J. Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering. J Orthop Res. 2018; 36 (1): 52–63. DOI: 10.1002/jor.23670

15. Juang Y.M., Lee C.Y., Hsu W.Y., et al. Proteomic analysis of chondrocytes exposed to pressure. Biomed Chromatogr. 2010; 24 (12): 1273–1282. DOI: 10.1002/bmc.1436

16. Mizuno S., Ogawa R. Using changes in hydrostatic and osmotic pressure to manipulate metabolic function in chondrocytes. Am J Physiol Cell Physiol. 2011; 300 (6): C1234– C1245. DOI: 10.1152/ajpcell.00309.2010

17. Karamesinis K., Spyropoulou A., Dalagiorgou G., et al. Continuous hydrostatic pressure induces differentiation phenomena in chondrocytes mediated by changes in polycystins, SOX9, and RUNX2. J Orofac Orthop. 2017; 78 (1): 21–31. DOI: 10.1007/s00056-016-0061-1

18. Sobol E.N., Baum O.I., Shekhter A.B., et al. Laser-induced regeneration of cartilage. J Biomed Opt. 2011; 16 (8): 080902. DOI: 10.1117/1.3614565

19. Alexandrovskaya Y.M., Baum O.I., Shekhter A.B., et al. Mechanisms of laser activation of chondrocytes in osteoarthritis healing. Laser Phys Lett. 2018; 15 (8): 085601. DOI: 10.1088/1612-202X/aac746

20. Shesternya N.A., Ivannikov S.V., Zharova T.A., et al. Clinical and biological aspects of gonarthrosis treatment. Clinical Gerontology. 2011; 17 (3–4): 37–47. [In Russ.].

21. Ivannikov S.V., et al. Laser chondroplasty – further development of knee arthroscopy. Moscow Surgical Journal. 2011; 19 (3): 40–43. [In Russ.].


Review

For citations:


Lychagin A.V., Ivannikov S.V., Yusupov V.I., Semenova L.A., Startseva E.D., Surin V.V., Tinkova I.O., Naimann A.I., Zharova T.A., Przhevalsky P.A., Yan Y. Laser treatment of chondromalacia lesions in the articular cartilage. Laser Medicine. 2021;25(4):9-15. (In Russ.) https://doi.org/10.37895/2071-8004-2021-25-4-9-15

Views: 1386


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2071-8004 (Print)
ISSN 2686-8644 (Online)