Narrow-band optical radiation of average wavelength 540 nm in the combined treatment of patients with progressive psoriasis

Purpose. To define the effectiveness of photochromotherapy (PCT) with narrow-band optical radiation of wavelength 540 nm (NBOR λ = 540 nm) in the complex therapy of patients with psoriasis. Material and methods. 57 patients with the verified diagnosis were taken into the trial: common psoriasis, progressive stage, non-seasonal form. All patients were randomized by the random number table into 3 clinically comparable groups: Group 1 (18 patients) had standard therapy; Group 2 (24 patients) had standard therapy plus PCT (NBOR λ = 540 nm); Placebo Group 3 (15 patients) had standard medicamentous therapy plus simulated effect of photochromotherapy. PCT with NBOR λ = 540 nm (green light) was performed using therapeutic device “Spectrum LC” laser-LED (model 02) simultaneously with the standard medicamentous therapy for 10 days. The following research techniques were used: clinical examination, psoriasis area and severity index (PASI), pruritus index BRS (behavioral rating scores), questionnaires (Spielberg–Khanin anxiety scale, Dermatology Life Quality Index – DLQI), ultrasonic dermascanning. Results. The complex therapy with NBOR λ = 540 nm resulted in : decreased PASI index from 15.6 to 7.1 points; PASI 55 – a significant decrease in psoriatic plaque thickness ; improved quality of life by 3.8 points; 100% reduction in the increased anxiety and 100% pruritus control. Conclusion. PCT (NBOR λ = 540 nm) applied for the treatment of progressive psoriatic stage has a statistically significant positive effect at the clinical course of the disease and at parameters of the Dermatological Life Quality Index (DLQI) as well as at the parameters of personal and situational anxiety.

psoriasis, progressive stage, physiotherapy, photochromotherapy, narrow-band optical radiation 540 nm

1. Adaskevich V.P. Diagnostic indices in dermatology. M.: Publisher Panfilova: BINOM. Laboratoria znaniy, 2014: 352. [In Russ.].

2. Astafieva N.G., Eremina M.G. Professional and social activity as important characteristics of the quality of life of able-bodied people with skin diseases. Sociologia medizini. 2012; 24 (1): 51–59. [In Russ.].

3. Batkaev E.A., Kuzmin S.G., Dimitriadi O.D. et al. The experience of applying photodynamic therapy with Photosens in dermatology. Russkiy medizinskiy zhurnal. 2013; 8: 406–407. [In Russ.].

4. Batrakov A.V., Khmelnitskaya N.M., Kiryanova V.V et al. The effect of blue light (470 nm) at the wound process in patients with facial furuncles. Profilakticheskaya i klinicheskaya medicina. 2011; 2: 89–92. [In Russ.].

5. Guzalov P.I. The effect of light irradiation at the pain intensity caused by the peripheral nerve damage. Vestnik Avicenni. 2012; 52 (3): 130–134. [In Russ.].

6. Dontsova E.V. Neuroendocrine parameters in patients with psoriasis associated with metabolic syndrome, and their dynamics during the treatment with low-level laser light. Nauchnie vedomosti. 2013; 25: 150–153. [In Russ.].

7. Dontsova E.V. The effectiveness of low-level laser blood irradiation at the cytokine status of patients with psoriasis. Nauchnie vedomosti Belgorodskogo gosudarstvennogo universiteta. 2014; 175 (4): 65–68. [In Russ.].

8. Kiryanova V.V., Aleksandrova V.A., Gordeychuk A.V. Narrow-band optical radiation of wavelength 540 nm in the complex treatment of children with chronic gastroduodenitis. Vestnik severo-zapadnogo gosudarstvennogo universiteta imeni I.I. Mechnikova. 2017; 9 (1): 102–106. [In Russ.].

9. Kiryanova V.V., Korolkova T.N., Kirillova A.S. LED radiation of wavelength 650 nm (red light) for the correction of involutional changes in the face skin . Vestnik Avicenni. 2012; 53 (4): 141–148. [In Russ.].

10. Moskvin S.V., Utz S.R., Schneider D.A. Combined laser therapy of patients with psoriasis, including the intravenous laser blood irradiation and topical treatment of foci. Lasernaya medicina. 2015: 19 (4): 44–48. [In Russ.].

11. Pliev K.T., Dvornikova E.V., Denisova E.V. et al. Photodynamic therapy in the complex treatment of patients with psoriasis. Klinicheskaya dermatologia i venerologia. 2017; 6: 110–114. [In Russ.].

12. Nikitin A.V., Gorbatykh M.F., Evstrakhova E.F. et al. Changes in the anti-inflammatory cytokines and oxidative status in patients with psoriatic arthritis during their treatment with the combination of arthrophone and low-level laser light. Vestnik novikh medizinskich technologiy. 2012; XIX (2): 260–263. [In Russ.].

13. Raznatovsky K.I., Terletsky O.V. Psoriatic disease. Diagnosis, therapy, prevention. M.: GEOTAR-Media, 2017: 352. [In Russ.].

14. Russian Society of Dermatovenerologists and Cosmetologists. Federal Clinical Guidelines for the Management of Psoriasis Patients. M.: Delovoy express, 2016: 786. [In Russ.].

15. Khadartsev A.A., Sazonova A.S., Belyaeva E.A. Devices for the experimental studies of laser phoresis and electro-ionophoresis. Vestnik novich medizinskich technologiy. 2016; 2: 265–283. [In Russ.].

16. Chepel E., Hayni M., Misbach S. et al. Fundamentals of clinical immunology. Translation from English. 5th ed. M.: GEOTARMedia, 2008: 416. [In Russ.].

17. Avci P., Gupta A., Sadasivam M. et al. Low-level laser light therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013; 32 (1): 41–52.

18. Oh P.S., Hwang H., Jeong H.S. et al. Blue light emitting diode induces apoptosis in lymphoid cells by stimulating autophagy. Int J Biochem Cell Biol. 2016; 70: 13–22.

19. Opländer C., Deck A., Volkmar C.M. et al. Mechanism and biological relevance of blue-light (420–453 nm) – induced nonenzymatic nitric oxide generation from photolabile nitric oxide derivates in human skin in vitro and in vivo. Int J Free Radic Biol Med. 2016; 65: 1363–1377.

20. Raghunath M., Beissert S., Schwarz T. Erfolgreiche Behandlung chronischin verterierter, therapierefraktarer Psoriasis Plaques mit photodynamischer Therapi. HG. 2000; 75 (3): 134–136.