Effects of low-level light at the functional activity and myocardium ultrastructure modified with ionizing radiation (an experimental study)

Purpose. To study effects of red broad-band light of low intensity at the electrical activity and microstructure of the myocardium after its exposing to gamma-radiation. Materials and methods. White mongrel rats were consequently irradiated by gamma-rays (apparatus LUCH-1) and low-level broad-band light (red emitting diode, wavelength 630 nm, spectral half-height 20 nm). 54 experimental animals were taken into the study. The researchers studied changes in ECG and in the cardiomyocyte microstructure caused by ionizing radiation (control groups) and by consequent exposure to gamma- and light flow (experimental groups) as compared to intact animals. The myocardium microstructure was studied using electronic microscope Morgagni 268D. Results. There was a statistically significant increase in QT, QTc intervals and R- and T-waves stress in the control groups and restoration of their values in the studied groups to levels observed in intact animals. Changes in the electrical activity of the heart were accompanied with changes in the myocardium microstructure. The authors describe a way how to restore them to the values corresponding to intact animals using phototherapeutic procedures. Conclusion. Irradiation of the projection of the heart with low-intensity broadband red light, previously exposed to gamma radiation, allows to reduce manifestations of radiation sickness at the cellular and sub-cellular levels

красный свет, ионизирующая радиация, ЭКГ, ультраструктура миокарда, red light, ionizing radiation, ECG, myocardium ultrastructure

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