Advantages of low-level pulsed red laser radiation in the treatment of chronic endometritis

Abstract

Purpose. To assess morphological, vascular, culture and immunohistochemical changes in the endometrium in women with chronic endometritis without exacerbation before and after the combined treatment in which a matrix red pulsed laser light with wavelength 635 nm was used. Materials and methods. 120 women were enrolled in the study. Their treatment included irradiation with low-level pulsed red laser light generated by laser device «Matrix» (wavelength 635 nm, pulse power 40 W, exposure 100-130 nsec). An original laser therapeutic technique was used for the treatment. 20 patients who had no laser therapy were controls. Histological and immunohistochemical tests in which lysozyme, CD68 macrophages, CD31 endothelial cell markers, CD56 + , CD16 + killer cells, and the activation marker of class II HLA-DR + were defined, were used by the researchers for endometritis diagnostics. For assessing the severity of chronic endometritis process a quantitative technique was used. Culture examination and polymerase chain reaction (PCR) helped to investigate endometrial microflora. Results. Matrix-assisted pulsed red laser (635 nm) has anti-inflammatory, immunomodulatory and vasoactive effects which can be successfully used for treating chronic endometritis. Conclusion. The studied type of laser is the most effective tool for the treatment for chronic endometritis.