Photodynamic therapy of penile leukoplakia: a case report
https://doi.org/10.37895/2071-8004-2021-25-3-29-33
Abstract
Purpose: to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin.
Material and methods. For PDT, chlorin-type photosensitizer “Photolon” was used. The photosensitizer (lyophilized powder) was diluted in 200.0 ml of 0.9 % sodium chloride solution, administered intravenously at dosage 1.5 mg/kg of body weight. After 2.5 hours, intravenous laser blood irradiation was performed with “Lakhta-Milon” laser device (output power – 100 mW, exposure – 30 minutes). Before PDT, fluorescence diagnostics in ultraviolet light with wavelength 395–405 nm was performed. PDT technique was single-field irradiation with output power 1800 mW (1.8 W), irradiation energy density – 150 J/cm2. Power density of laser light was 200 mW/cm2. Exposure time – 14 min.
Results. After treatment, complete regression of the pathological focus and regeneration of healthy tissue were marked (one month).
Conclusion. PDT in a patient with leukoplakia of glans penis is an effective and safe curative technique.
About the Authors
N. A. Shanazarov
Hospital of Medical Center of Administration of Presidential Affairs
Kazakhstan
Kazakhstan
Shanazarov Nasrulla – Dr. Sc. (Med.), Professor, Oncologist, Deputy Director.
Nur-Sultan
B. G. Kassymov
Hospital of Medical Center of Administration of Presidential Affairs
Kazakhstan
Kazakhstan
Kassymov Bakhtiyar – Urologist.
Nur-Sultan
T. M. Muratov
Hospital of Medical Center of Administration of Presidential Affairs
Kazakhstan
Kazakhstan
Muratov Timur – Urologist.
Nur-Sultan
S. V. Zinchenko
Republican Clinical Oncological Dispensary; Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Zinchenko Sergey – Dr. Sc. (Med.), Docent, Oncologist, Republican Clinical Oncological Dispensary; Head of the Department of Surgery, Obstetrics and Gynecology, KFU.
Kazan
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Review
For citations:
Shanazarov N.A., Kassymov B.G., Muratov T.M., Zinchenko S.V. Photodynamic therapy of penile leukoplakia: a case report. Laser Medicine. 2021;25(3):29-33. (In Russ.) https://doi.org/10.37895/2071-8004-2021-25-3-29-33
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