Cerebroprotective effect of helium-neon laser irradiation of blood in the surgical endotoxkosis

The endogenous intoxication syndrome is a predictor of polyorganic and polysystemic failure. Experimental work has been done to study the antiradical effect of low-intensity laser irradiation in peritoneal endotoxicosis in mongrel dogs. Intravascular laser blood irradiation (wavelength 635 nm) with radiation power output 2 mW and exposure time 15 min. was used in the experimental group in addition to standard therapy. Acute experimental peritonitis resulted in a significant increase of hydrophilic and hydrophobic toxins in blood plasma of experimental animals. Standard infusions and antibiotic therapy did not normalize biochemical parameters in blood plasma. Laser therapy significantly reduced endotoxemia severity. A significant restructure of the lipid and phospholipid spectrum in cerebral membranes during peritonitis was noted. A significant increase of detergent forms of lipids was also recorded what indicates degradation of biological membranes. Low-level laser blood irradiation reduced the intensity of membrane destruction and inhibited phospholipase A₂ activity in cerebral tissue comparing to the control group. The obtained results demonstrate that laser therapy decreases intoxication levels in blood plasma and reduces the intensity of lipid peroxidation in brain tissue. Thus, we can state that such laser application may be perspective for cerebroprotective purpose in peritoneal endointoxication.

эндогенная интоксикация, головной мозг, лазеротерапия, липиды, endogenous intoxication, brain, laser therapy, lipids

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