Photodynamic therapy for treating malignant skin tumors in young people
https://doi.org/10.37895/2071-8004-2020-24-2-3-15-21
Abstract
Objective: to study the effectiveness of photodynamic therapy (PDT) for non-melanoma malignant skin neoplasms with photosensitizer (PS) Photolon in young patients. Material and methods. 59 patients, aged 19–44, with verified diagnosis were treated with PDT technique: basal cell skin cancer (BCSC) – 51 patient; squamous cell skin cancer (SCSC) – 8 patients. Photolon dose was 0.8–1.3 mg/kg. The applied light dose was from 100 to 400 J/cm 2 depending on the clinical and histological form of tumor focus and the contrast index of PS – tumor / healthy skin calculated by findings of fluorescent diagnostics. Results. 6 months after PDT, 84.7% patients with non-melanoma skin cancer cT1-4N0M0 had a complete regression; 11.9% – partial; 3.4% – stabilization. There was a good cosmetic effect as well. It has been revealed that PDT effectiveness in BCSC is higher than that in squamous cell skin cancer; complete regressions was seen in 92.2 and 37.5%, respectively. Relapses during the follow-up period (from 6 months to 10 years) were registered in 8.7% of cases. Conclusion. PDT with Photolon is an effective technique for treating non-melanoma skin cancer with low risk of developing anatomical and functional disorders. It may be a method of choice for treating young people with malignant skin neoplasms.
About the Authors
E. V. Yaroslavtseva-Isaeva
A. Tsyb Medical Radiological Research Center
Russian Federation
Russian Federation
Elena Yaroslavtseva-Isaeva – MD, candidate of medical sciences, leading researcher at department of PDD and therapy
Obninsk
M. A. Kaplan
A. Tsyb Medical Radiological Research Center
Russian Federation
Russian Federation
Mikhail Kaplan – MD, doctor of medical sciences, professor, chief researcher of department of PDD and Therapy
Obninsk
V. N. Kapinus
A. Tsyb Medical Radiological Research Center
Russian Federation
Russian Federation
Viktoria Kapinus – MD, candidate of medical sciences, physician at department of PDD and therapy
Obninsk
I. S. Spichenkova
A. Tsyb Medical Radiological Research Center
Russian Federation
Russian Federation
Irina Spichenkova – MD, candidate of medical sciences, researcher at department of PDD and Therapy
Obninsk
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Review
For citations:
Yaroslavtseva-Isaeva E.V., Kaplan M.A., Kapinus V.N., Spichenkova I.S. Photodynamic therapy for treating malignant skin tumors in young people. Laser Medicine. 2020;24(2-3):15-21. (In Russ.) https://doi.org/10.37895/2071-8004-2020-24-2-3-15-21
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