Photosensitizer accumulation in the bladder mucosa in chronic cystitis
A. V. Baranov, 
A. I. Kornev,
A. A. Boriskin,
R. D. Mustafayev,
V. A. Derbenev,
D. S. Gorin,
K. T. Efendiyev
A. I. Kornev,
A. A. Boriskin,
R. D. Mustafayev,
V. A. Derbenev,
D. S. Gorin,
K. T. Efendiyev https://doi.org/10.37895/2071-8004-2020-24-2-3-9-14
Abstract
Purpose. To study the accumulation of photosensitizer Photoditazine in the bladder mucous in chronic cystitis. Material and methods. 22 patients with chronic cystitis were taken into the study. The time of Photoditazine accumulation in the bladder mucous was determined with a multi-channel optical fiber spectroanalyzer («LESA-01-BIOSPEC»). Photodynamic therapy (PDT) was done with laser «ATKUS-2» having adjustable output power up to 2 W and wavelength 661 ± 0.03 nm. Results. The performed fluorescence spectroscopy has revealed that the maximal accumulation time of Photoditazine in the bladder mucous in chronic cystitis is 120–150 minutes. After laser exposure, by spectroscopy finings, fluorescence intensity decreases by 72.3% which indicates a pronounced photosensitizer excitation and an active photodynamic reaction. Conclusion. The optimal time for laser photodynamic therapy in chronic cystitis is 2–2.5 hours after photosensitizer injection. Spectroscopy findings after laser exposure demonstrate the effectiveness of photodynamic therapy in chronic cystitis.
About the Authors
A. V. Baranov
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Russian Federation
Baranov Alexey – MD, Dr. Sc. (med), director
Studencheskaya street 40, Moscow
A. I. Kornev
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Russian Federation
Kornev Alexey – MD, Cand. Sc. (med), head of department of laser technologies in urology
Moscow
A. A. Boriskin
State Hospital for War Veterans No 2
Russian Federation
Russian Federation
Boriskin Alexey – MD, head of urology department
Moscow
R. D. Mustafayev
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Russian Federation
Mustafayev Rovshan – MD, Dr. Sc. (med), head of department of general laser surgery
Moscow
V. A. Derbenev
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Russian Federation
Derbenev Valentin – MD. Dr. Sc. (med), professor, chief researcher
Moscow
D. S. Gorin
State Hospital for War Veterans No 2
Russian Federation
Russian Federation
Gorin Dmitry – MD, otorhinolaryngologist
Moscow
K. T. Efendiyev
National Research Nuclear University «MEPhI»
Russian Federation
Russian Federation
Efendiev Kanamat – post-graduate student
Moscow
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Review
For citations:
Baranov A.V., Kornev A.I., Boriskin A.A., Mustafayev R.D., Derbenev V.A., Gorin D.S., Efendiyev K.T. Photosensitizer accumulation in the bladder mucosa in chronic cystitis. Laser Medicine. 2020;24(2-3):9-14. (In Russ.) https://doi.org/10.37895/2071-8004-2020-24-2-3-9-14
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