Assessment of reparative processes of in the eye tissues after ablation of the sclera with excimer laser so as to enhance intraocular fluid outflow (experimental study)

The modern trend in surgical technologies is to develop safe and effective approaches for treating patients with various nosologies. Lately, ophthalmic surgeons have been actively looking for new techniques which can give a long-lasting hypotensive effect in patients with glaucoma and can have a low risk of complications. Stimulation of the uveoscleral outflow pathway for the eye fluid is among mostly interesting ones. In this case, sclera becomes a final stage of intraocular fluid flow out of the eye, so the role of its regenerative abilities is of great importance. Multi-year studies showed that light from the eximer laser has a positive temperature effect at the cornea during refractive surgery. Previous experiments on human cadaver eyes showed that thinner sclera has better permeability and has better coefficient of eye fluid outflow. The aim of the present study was to assess the state of eye tissues and reparative processes in them after excimer laser ablation and surgical resection of sclera in vivo. Experiments were conducted on 20 eyes of 10 rabbits of the Chinchilla breed. Excimer laser ablation of sclera to the depth of 200 цш on the right eye was performed using Russian-made excimer laser «MicroScan Vizum» with wavelength 193 нм (0.193 цш); resection of sclera area of 7.0 x 5.0 mm to 2/3 of its thickness was performed with a surgical blade on the left eye. Histological examination was made with stains Hematoxylin, Eosin and Pikrofuksin by Van Gieson. In two months after the excimer laser ablation of sclera, one could see completed regeneration and no inflammatory processes in eye tissues.

склера, глаукома, увеосклеральный отток, эксимерлазерная абляция, эксимерный лазер, регенерация, sclera, glaucoma, uveoscleral outflow, excimer laser ablation, excimer laser, regeneration

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