goslasmedЛазерная медицинаLaser Medicine2071-80042686-8644Skobelkin Centre for Laser Medicine - a branch of the Federal Clinical Center for High Medical Technologies, FMBA of Russia10.37895/2071-8004-2021-25-4-42-50goslasmed-758Research ArticleОБЗОРЫREVIEWSИспользование рaмaн-флуоресцентных технологий в ранней диагностике воспалительных и опухолевых заболеваний как часть стратегического направления формирования общественного здоровья и инструмент для повышения качества оказания медицинской помощи: обзор литературыRaman fl uorescence technologies for early detection of infl ammatory and oncological disorders as a part of public health strategy and a tool for improving the quality of medical care: a reviewhttps://orcid.org/0000-0003-1817-3228ТимурзиеваА. Б.TimurzievaA. B.

Тимурзиева Алина Борисовна – кандидат медицинских наук, врач-оториноларинголог, научный сотрудник отдела экономических исследований в здравоохранении

Москва

Timurziеva Alinа – Cand. Sc. (Med.), Otorhinolaryngologist, Researcher at the Department of Economic Researches in Healthcare

Moscow

alinko9977z@mail.ruФГБНУ «Национальный НИИ Общественного здоровья им. Н.А. Семашко»РоссияN.A. Semashko National Research Institute of Public HealthRussian Federation2021170420222544250Copyright © Тимурзиева А.Б., 20222022Тимурзиева А.Б.Timurzieva A.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://goslasmed.elpub.ru/jour/article/view/758

Увеличение заболеваемости и смертности от воспалительных и опухолевых заболеваний требует определения стратегических направлений формирования общественного здоровья, направленных на раннюю их идентификацию и, как следствие, повышение качества  оказания медицинской помощи. Для данной цели необходима разработка высокотехнологичных вмешательств, позволяющих проводить  диагностику с высокой чувствительностью, специфичностью, точностью, в экспресс-режиме и неинвазивно. Рaман-флуоресцентные  медицинские технологии могут быть успешно использованы в диагностике воспалительных и опухолевых заболеваний различной  локализации при разработке специального алгоритма экспресс-анализа гистологической, физиологической, микробиологической  и других составляющих исследуемых биологических тканей. В данной рукописи приведен краткий обзор использования метода рaман-флуоресцентной спектрометрии в диагностике заболеваний различных органов и систем. Медицинская технология, основанная  на явлении аутофлуоресценции тканей и эффекте рамановского рассеяния света, может стать перспективным методом ранней  диагностики воспалительных и опухолевых заболеваний различных органов и систем и служить дополняющим способом в практике  врачей. Описанная в данной статье медицинская неинвазивная технология позволяет проводить экспресс-оценку метаболических,  морфометрических и функциональных показателей ткани в норме и при патологии. Предметом данного обсуждения является определение границ применения раман-флуoресцентной спектрометрии в различных ее модификациях; оценка возможности использования ее  в качестве скрининговой методики; разработка специального aлгоритма диагностики патологии воспалительной и опухолевой этиологии.  Предлагаемый метод диагностики может быть использован в перспективе для повышения качества оказания медицинской помощи  с использованием раман-флуоресцентных медицинских технологий с целью выявления воспалительных и опухолевых заболеваний  на ранней стадии и назначения своевременной рациональной терапии.

The increasing morbidity and mortality rate in inflammatory and oncological diseases requires determining the public health strategies for early  detection of such disorders and improving the quality of medical care. For this goal, high-tech modalities with high sensitivity, specificity and  accuracy are to be worked out. Rаman fluorescent medical technologies (RFMT) can be successfully applied in the diagnostics of inflammatory  and tumor diseases if to develop a specific algorithm for express analysis of histological, physiological, microbiological and other components  of biological tissues. The given article presents a brief overview on the application of Raman fluorescence spectrometry in the diagnostics  of diseases. This medical technology, which utilizes the phenomenon of tissue autoflorescence and Raman light scattering, is a promising  tool for early diagnostics of different inflammatory and oncological pathologies. The described nоn-invasive method allows to make an express  assessment of metabolic, morphometric and functional tissue parameters in intact and in pathological tissue. The present discussion is aimed  to find out points for the application of Rаman fluorescence spectrometry and its various modifications; to assess its potentials for screening;  to develop a specific algorithm for the diagnostics of inflammatory and tumor pathologies. RFMT is a promising modality for future applications  so as to improve the quality of medical care by early detection of inflammatory and tumor diseases and early prescription of rational therapy.

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The authors declare that there are no conflicts of interest present.