<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">goslasmed</journal-id><journal-title-group><journal-title xml:lang="ru">Лазерная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Laser Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8004</issn><issn pub-type="epub">2686-8644</issn><publisher><publisher-name>Skobelkin Centre for Laser Medicine - a branch of the Federal Clinical Center for High Medical Technologies, FMBA of Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37895/2071-8004-2017-21-2-50-54</article-id><article-id custom-type="elpub" pub-id-type="custom">goslasmed-358</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Лазерные методики в эндоскопической диагностике неоплазий толстой кишки</article-title><trans-title-group xml:lang="en"><trans-title>Laser techniques in the endoscopic diagnostics of colon neoplasia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуванский</surname><given-names>Владимир Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Duvansky</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">iva4583@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belkov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дикалова</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dikalova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «ГНЦ ЛМ ФМБА России»; РУДН<country>Россия</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «ГНЦ ЛМ ФМБА России»<country>Россия</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">РУДН<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>03</day><month>08</month><year>2018</year></pub-date><volume>21</volume><issue>2</issue><fpage>50</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дуванский В.А., Белков А.В., Дикалова Э.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Дуванский В.А., Белков А.В., Дикалова Э.А.</copyright-holder><copyright-holder xml:lang="en">Duvansky V.A., Belkov A.V., Dikalova E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://goslasmed.elpub.ru/jour/article/view/358">https://goslasmed.elpub.ru/jour/article/view/358</self-uri><abstract><p>В обзоре литературы проведен анализ современных лазерных технологий эндоскопического осмотра толстой кишки. Появление в последние десятилетия дополнительных технологий осмотра, таких как аутофлюоресцентная диагностика, фотодинамическая диагностика, оптическая когерентная томография, конфокальная лазерная эндомикроскопия, изображение при помощи голубого лазера, значительно повысили ценность эндоскопических исследований. Приведены результаты оценки эффективности современных лазерных технологий в эндоскопической диагностике новообразований толстой кишки. Целью аутофлюоресцентной диагностики, фотодинамической диагностики является выявление поверхностных эпителиальных структур, что достижимо за счет применения оптических фильтров и пост-компьютерной обработки изображений. Оптическая когерентная томография и конфокальная лазерная эндомикроскопия позволяют проводить дифференциальную диагностику новообразований. Проведен анализ работ по оценке эффективности лазерных методик эндоскопической диагностики новообразований толстой кишки. Применение лазерных методик эндоскопической визуализации позволяет повысить эффективность диагностики неоплазий толстой кишки, их внедрение в клиническую практику и анализ результатов применения является перспективным направлением клинической эндоскопии.</p></abstract><trans-abstract xml:lang="en"><p>The present literature review analyzes modern laser techniques used for the endoscopic examination of the colon. The recently appeared diagnostic techniques, such as autofluorescent diagnostics, photodynamic diagnostics, optical coherence tomography, confocal laser endomicroscopy and blue laser imaging, have significantly increased the value of endoscopic examinations. The authors assess the effectiveness of modern laser technologies in endoscopic diagnostics of colon neoplasms. The goal of autofluorescent diagnostics and photodynamic diagnostics is to detect superficial epithelial structures with optical filters and post-computer image processings. Differential diagnostics of neoplasms became possible due to optical coherence tomography and confocal laser endomicroscopy. The authors have also analyzed the effectiveness of laser techniques in endoscopic diagnostics of colon neoplasms. Endoscopic laser diagnostic techniques increase the accuracy in detecting colon neoplasms. These techniques, being applied in clinical practice, open new horizons in clinical endoscopy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>колоректальный рак</kwd><kwd>эндоскопия</kwd><kwd>лазерная диагностика</kwd><kwd>colorectal cancer</kwd><kwd>endoscopy</kwd><kwd>laser diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Агейкина Н.В., Дуванский В.А., Князев М.В. Альтернативный путь развития колоректального рака. Эндоскопические и морфологические особенности зубчатых поражений // Экспериментальная и клиническая гастроэнтерология. - 2013. - № 8. - С. 3-10.</mixed-citation><mixed-citation xml:lang="en">Агейкина Н.В., Дуванский В.А., Князев М.В. Альтернативный путь развития колоректального рака. Эндоскопические и морфологические особенности зубчатых поражений // Экспериментальная и клиническая гастроэнтерология. - 2013. - № 8. - С. 3-10.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Агейкина Н.В., Дуванский В.А., Князев М.В. и др. Альтернативный путь развития колоректального рака. Гистогенетические и молекулярные особенности зубчатых поражений // Экспериментальная и клиническая гастроэнтерология. - 2014. - № 7 (107). - С. 4-12.</mixed-citation><mixed-citation xml:lang="en">Агейкина Н.В., Дуванский В.А., Князев М.В. и др. Альтернативный путь развития колоректального рака. Гистогенетические и молекулярные особенности зубчатых поражений // Экспериментальная и клиническая гастроэнтерология. - 2014. - № 7 (107). - С. 4-12.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Балалыкин А.С. Эндоскопическая абдоминальная хирургия. -ИМА-пресс. -1996. -144 с.</mixed-citation><mixed-citation xml:lang="en">Балалыкин А.С. Эндоскопическая абдоминальная хирургия. -ИМА-пресс. -1996. -144 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Бунцева О.А., Галкова З.В., Плахов Р.В. и др. Современная эндоскопическая диагностика предраковых изменений и раннего рака желудка и толстой кишки с применением компьютерных систем поддержки принятия решений // Экспериментальная и клиническая гастроэнтерология. - 2014. - № 10. - С. 88-96.</mixed-citation><mixed-citation xml:lang="en">Бунцева О.А., Галкова З.В., Плахов Р.В. и др. Современная эндоскопическая диагностика предраковых изменений и раннего рака желудка и толстой кишки с применением компьютерных систем поддержки принятия решений // Экспериментальная и клиническая гастроэнтерология. - 2014. - № 10. - С. 88-96.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Денисенко А.Н. Оптическая когерентная томография в диагностике новообразований желудочно-кишечного тракта // Дисс.. канд. мед. наук. - 2006. - С. 60-78.</mixed-citation><mixed-citation xml:lang="en">Денисенко А.Н. Оптическая когерентная томография в диагностике новообразований желудочно-кишечного тракта // Дисс.. канд. мед. наук. - 2006. - С. 60-78.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дуванский В.А., Князев М.В., Праведников П.В. Современные аспекты фотодинамической терапии заболеваний пищевода // Экспериментальная и клиническая гастроэнтерология. -2011. - № 10. - С. 111-116.</mixed-citation><mixed-citation xml:lang="en">Дуванский В.А., Князев М.В., Праведников П.В. Современные аспекты фотодинамической терапии заболеваний пищевода // Экспериментальная и клиническая гастроэнтерология. -2011. - № 10. - С. 111-116.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дуванский В.А., Князев М.В., Краев Г.П., Осин В.Л. Эндоскопия в узком спектре и оптическая когерентная томография в диагностике толстокишечных неоплазий // Эндоскопическая хирургия. - 2013. - Т. 1. - С. 206.</mixed-citation><mixed-citation xml:lang="en">Дуванский В.А., Князев М.В., Краев Г.П., Осин В.Л. Эндоскопия в узком спектре и оптическая когерентная томография в диагностике толстокишечных неоплазий // Эндоскопическая хирургия. - 2013. - Т. 1. - С. 206.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Дуванский В.А., Князев М.В., Краев Г.П. Фотодинамическая терапия в эндоскопическом лечении гастроинтестинальных опухолей // Лазерная медицина. - 2014. - Т. 18. - № 2. - С. 49-53.</mixed-citation><mixed-citation xml:lang="en">Дуванский В.А., Князев М.В., Краев Г.П. Фотодинамическая терапия в эндоскопическом лечении гастроинтестинальных опухолей // Лазерная медицина. - 2014. - Т. 18. - № 2. - С. 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Дуванский В.А., Князев М.В. Эндоскопическое лечение гастроинтестинальных неоплазий - эволюция метода // Вестник хирургии им. И.И. Грекова. - 2015. - Т. 174. - № 2. - С. 130-134.</mixed-citation><mixed-citation xml:lang="en">Дуванский В.А., Князев М.В. Эндоскопическое лечение гастроинтестинальных неоплазий - эволюция метода // Вестник хирургии им. И.И. Грекова. - 2015. - Т. 174. - № 2. - С. 130-134.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Загайнова Е.В., Загайнов В.Е., Гладкова Н.Д. и др. Оптическая когерентная томография при хирургическом лечении рака пищевода // Вестник хирургии им. И.И. Грекова. - 2007. -Т. 166. - № 2. - С. 22-26.</mixed-citation><mixed-citation xml:lang="en">Загайнова Е.В., Загайнов В.Е., Гладкова Н.Д. и др. Оптическая когерентная томография при хирургическом лечении рака пищевода // Вестник хирургии им. И.И. Грекова. - 2007. -Т. 166. - № 2. - С. 22-26.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Князев М.В., Дуванский В.А., Агейкина Н.В. Тримодальная эндоскопия в диагностике заболеваний желудочно-кишечного тракта // Клиническая эндоскопия. - 2012. - Т. 4. - С. 2.</mixed-citation><mixed-citation xml:lang="en">Князев М.В., Дуванский В.А., Агейкина Н.В. Тримодальная эндоскопия в диагностике заболеваний желудочно-кишечного тракта // Клиническая эндоскопия. - 2012. - Т. 4. - С. 2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Князев М.В., Дуванский В.А. Аутофлуоресцентная эндоскопия в диагностике колоректальных неоплазий // Эндоскопическая хирургия. - 2014. - № 1. - С. 186.</mixed-citation><mixed-citation xml:lang="en">Князев М.В., Дуванский В.А. Аутофлуоресцентная эндоскопия в диагностике колоректальных неоплазий // Эндоскопическая хирургия. - 2014. - № 1. - С. 186.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Князев М.В., Дуванский В.А., Агейкина Н.В. Аутофлуоресцентная диагностика эпителиальных образований желудка // Лазерная медицина. - 2014. - Т. 18. - № 2. - С. 20-26.</mixed-citation><mixed-citation xml:lang="en">Князев М.В., Дуванский В.А., Агейкина Н.В. Аутофлуоресцентная диагностика эпителиальных образований желудка // Лазерная медицина. - 2014. - Т. 18. - № 2. - С. 20-26.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Князев М.В., Дуванский В.А. Эндоскопическая резекция слизистой с диссекцией подслизистого слоя - 20 лет спустя (обзор зарубежной литературы) // Экспериментальная и клиническая гастроэнтерология. - 2015. - № 4 (116). - С. 53-58.</mixed-citation><mixed-citation xml:lang="en">Князев М.В., Дуванский В.А. Эндоскопическая резекция слизистой с диссекцией подслизистого слоя - 20 лет спустя (обзор зарубежной литературы) // Экспериментальная и клиническая гастроэнтерология. - 2015. - № 4 (116). - С. 53-58.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Шулешова А.Г., Брехов Е.И., Завьялов М.О. и др. Конфокальная лазерная эндомикроскопия в диагностике неоплазий желудка // Эндоскопическая хирургия. - 2014. - № 5. - С. 24-30.</mixed-citation><mixed-citation xml:lang="en">Шулешова А.Г., Брехов Е.И., Завьялов М.О. и др. Конфокальная лазерная эндомикроскопия в диагностике неоплазий желудка // Эндоскопическая хирургия. - 2014. - № 5. - С. 24-30.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">ASGE Technology Committee: Confocal laser endomicroscopy // Gastrointest Endosc. - 2014. - 80 (6). - P. 928-38.</mixed-citation><mixed-citation xml:lang="en">ASGE Technology Committee: Confocal laser endomicroscopy // Gastrointest Endosc. - 2014. - 80 (6). - P. 928-38.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bergholt M.S., Lin K., Wang J. et al. Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy enhances real-time in vivo diagnosis of adenomatous polyps during colonoscopy // J. Biophotonics. - 2016. - 9. - P. 333-342.</mixed-citation><mixed-citation xml:lang="en">Bergholt M.S., Lin K., Wang J. et al. Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy enhances real-time in vivo diagnosis of adenomatous polyps during colonoscopy // J. Biophotonics. - 2016. - 9. - P. 333-342.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bergholt M.S., Zheng W., Ho K.Y. et al. Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett’s esophagus // Gastroenterology. - 2014. - 146. - P. 27-32.</mixed-citation><mixed-citation xml:lang="en">Bergholt M.S., Zheng W., Ho K.Y. et al. Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett’s esophagus // Gastroenterology. - 2014. - 146. - P. 27-32.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bergholt M.S., Zheng W., Lin K. et al. Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy // Anal. Chem. - 2015. - 87. - P. 960-966.</mixed-citation><mixed-citation xml:lang="en">Bergholt M.S., Zheng W., Lin K. et al. Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy // Anal. Chem. - 2015. - 87. - P. 960-966.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Canto M.I., Anandasabapathy S., Brugge W. et al. In vivo endomicroscopy improves detection of Barrett’s esophagus-related neoplasia: a multicenter international randomized controlled trial (with video) // Gastrointest Endosc. - 2014. - 79 (2). - P. 211-21.</mixed-citation><mixed-citation xml:lang="en">Canto M.I., Anandasabapathy S., Brugge W. et al. In vivo endomicroscopy improves detection of Barrett’s esophagus-related neoplasia: a multicenter international randomized controlled trial (with video) // Gastrointest Endosc. - 2014. - 79 (2). - P. 211-21.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Csanady M., Kiss J.G., Ivan L., Jori J., Czigner J. et al. ALA (5-aminolevulinic acid) -induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer. Eur Arch Otorhinolaryngol. - 2004 May. - 261 (5). -P. 262-266. Epub 2003 Sep 3.</mixed-citation><mixed-citation xml:lang="en">Csanady M., Kiss J.G., Ivan L., Jori J., Czigner J. et al. ALA (5-aminolevulinic acid) -induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer. Eur Arch Otorhinolaryngol. - 2004 May. - 261 (5). -P. 262-266. Epub 2003 Sep 3.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Degen A., Gabrecht T., Wagnières G. et al. Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: in vivo study // Lasers Surg Med. - 2005 Mar. - 36 (3). - P. 234-7.</mixed-citation><mixed-citation xml:lang="en">Degen A., Gabrecht T., Wagnières G. et al. Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: in vivo study // Lasers Surg Med. - 2005 Mar. - 36 (3). - P. 234-7.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Douvansky V.A. Kniazev M.V. Autofluorescent endoscopic diagnostics of epithelial neoplasms in the colon // Journal of Gastroenterology and Hepatology. - 2015. - 30 (Suppl. 4). - P. 211.</mixed-citation><mixed-citation xml:lang="en">Douvansky V.A. Kniazev M.V. Autofluorescent endoscopic diagnostics of epithelial neoplasms in the colon // Journal of Gastroenterology and Hepatology. - 2015. - 30 (Suppl. 4). - P. 211.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimoto J.G., Brezinski M.E., Tearney G.J. et al. «Optical biopsy and imaging using optical coherence tomography,» // Nat. Med. -1995. - 1 (9). - P. 970-972.</mixed-citation><mixed-citation xml:lang="en">Fujimoto J.G., Brezinski M.E., Tearney G.J. et al. «Optical biopsy and imaging using optical coherence tomography,» // Nat. Med. -1995. - 1 (9). - P. 970-972.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Haringsma J., Tytgat G.N., Yano H. et al. Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology // Gastrointest Endosc. - 2001. - 53. - P. 642-650.</mixed-citation><mixed-citation xml:lang="en">Haringsma J., Tytgat G.N., Yano H. et al. Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology // Gastrointest Endosc. - 2001. - 53. - P. 642-650.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hiroko Inomata, Naoto Tamai, Hiroyuki Aihara et al. Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions // World. J. Gastroenterol. - 2013 November 7. - 19 (41). - P. 7146-7153.</mixed-citation><mixed-citation xml:lang="en">Hiroko Inomata, Naoto Tamai, Hiroyuki Aihara et al. Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions // World. J. Gastroenterol. - 2013 November 7. - 19 (41). - P. 7146-7153.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ishizuka M., Abe F., Sano Y. et al. Novel development of 5-aminolev-urinic acid (ALA) in cancer diagnoses and therapy // Int. Immunopharmacol. - 2011. - 11. - Р 358-365 [PMID: 21144919 DOI: 10.1016/j.intimp.2010.11.029].</mixed-citation><mixed-citation xml:lang="en">Ishizuka M., Abe F., Sano Y. et al. Novel development of 5-aminolev-urinic acid (ALA) in cancer diagnoses and therapy // Int. Immunopharmacol. - 2011. - 11. - Р 358-365 [PMID: 21144919 DOI: 10.1016/j.intimp.2010.11.029].</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kaneko Kazuhiro, Yasuhiro Oono et al. Effect of novel bright image enhanced endoscopy using blue laser imaging (BLI) // Endoscopy International Open. - 2014. - 02. - P. E212-E219.</mixed-citation><mixed-citation xml:lang="en">Kaneko Kazuhiro, Yasuhiro Oono et al. Effect of novel bright image enhanced endoscopy using blue laser imaging (BLI) // Endoscopy International Open. - 2014. - 02. - P. E212-E219.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kara M.A., Peters F.P., Ten Kate F.J. et al. Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus // Gastrointest Endosc. - 2005. - 61. - P. 679-685.</mixed-citation><mixed-citation xml:lang="en">Kara M.A., Peters F.P., Ten Kate F.J. et al. Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus // Gastrointest Endosc. - 2005. - 61. - P. 679-685.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kato M., Kaise M., Yonezawa J. et al. Autofluorescence endoscopy versus conventional white light endoscopy for the detection of superficial gastric neoplasia: a prospective comparative study // Endoscopy. - 2007. - 39. - P. 937-941.</mixed-citation><mixed-citation xml:lang="en">Kato M., Kaise M., Yonezawa J. et al. Autofluorescence endoscopy versus conventional white light endoscopy for the detection of superficial gastric neoplasia: a prospective comparative study // Endoscopy. - 2007. - 39. - P. 937-941.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kniazev M.V., Douvansky VA. Autofluorescence of the epithelial neoplasia in the stomach // J. of Gastroen. and Hepatol. - 13. -Т. 28. - № S3. - P. 718.</mixed-citation><mixed-citation xml:lang="en">Kniazev M.V., Douvansky VA. Autofluorescence of the epithelial neoplasia in the stomach // J. of Gastroen. and Hepatol. - 13. -Т. 28. - № S3. - P. 718.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Li C.Q., Zuo X.L., Guo J. et al. Comparison between two types of confocal laser endomicroscopy in gastrointestinal tract // J. Dig. Dis. - 2015. - 16 (5). - P. 279-85.</mixed-citation><mixed-citation xml:lang="en">Li C.Q., Zuo X.L., Guo J. et al. Comparison between two types of confocal laser endomicroscopy in gastrointestinal tract // J. Dig. Dis. - 2015. - 16 (5). - P. 279-85.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Liang C.P., Wierwille J., Moreira T. et al. «A forwardimaging needle-type OCT probe for image guided stereotactic procedures» // Opt. Express 2011. - 19 (27). - P. 26283-26294.</mixed-citation><mixed-citation xml:lang="en">Liang C.P., Wierwille J., Moreira T. et al. «A forwardimaging needle-type OCT probe for image guided stereotactic procedures» // Opt. Express 2011. - 19 (27). - P. 26283-26294.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Moore G.E., Peyton W.T. The clinical use of fluorescein in neurosurgery; the localization of brain tumors // J Neurosurg 1948; 5:392-398 [PMID: 18872412 DOI: 10.3171/jns.1948.5.4.0392].</mixed-citation><mixed-citation xml:lang="en">Moore G.E., Peyton W.T. The clinical use of fluorescein in neurosurgery; the localization of brain tumors // J Neurosurg 1948; 5:392-398 [PMID: 18872412 DOI: 10.3171/jns.1948.5.4.0392].</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Munetaka Nakamura, Jun Nishikawa, Kouichi Hamabe et al. Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors // World. J. Gastroenterol. -2015 June 7. - 21 (21). - P. 6706-6712.</mixed-citation><mixed-citation xml:lang="en">Munetaka Nakamura, Jun Nishikawa, Kouichi Hamabe et al. Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors // World. J. Gastroenterol. -2015 June 7. - 21 (21). - P. 6706-6712.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Neumann H., Kiesslich R., Wallace M.B. et al. Confocal laser endomicroscopy: technical advances and clinical applications // Gastroenterology. - 2010. - 139 (2). - 388-92, 392. - P. e1-2.</mixed-citation><mixed-citation xml:lang="en">Neumann H., Kiesslich R., Wallace M.B. et al. Confocal laser endomicroscopy: technical advances and clinical applications // Gastroenterology. - 2010. - 139 (2). - 388-92, 392. - P. e1-2.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sergeev A., Gelikonov V., Gelikonov G. et al. In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa // Opt. Express. - 1997. - 1 (13). - P. 432-440.</mixed-citation><mixed-citation xml:lang="en">Sergeev A., Gelikonov V., Gelikonov G. et al. In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa // Opt. Express. - 1997. - 1 (13). - P. 432-440.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Stenzl A., Burger M., Fradet Y. et al. Hexaminolevulinate guided fluorescence cystoscopy reduces recurrence in patients with nonmuscle invasive bladder cancer // J. Urol. 2010, Nov. - 184 (5). -Р 1907-13. doi: 10.1016/j.juro.2010.06.148. Epub 2010 Sep 17.</mixed-citation><mixed-citation xml:lang="en">Stenzl A., Burger M., Fradet Y. et al. Hexaminolevulinate guided fluorescence cystoscopy reduces recurrence in patients with nonmuscle invasive bladder cancer // J. Urol. 2010, Nov. - 184 (5). -Р 1907-13. doi: 10.1016/j.juro.2010.06.148. Epub 2010 Sep 17.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tope W.D., Ross E.V., Kollias N. et al. Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid // Photochem Photobiol. - 1998. - 67. - Р. 249-255 [PMID: 9487802 DOI: 10.1111/j.1751-1097.1998.tb05194.x].</mixed-citation><mixed-citation xml:lang="en">Tope W.D., Ross E.V., Kollias N. et al. Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid // Photochem Photobiol. - 1998. - 67. - Р. 249-255 [PMID: 9487802 DOI: 10.1111/j.1751-1097.1998.tb05194.x].</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Torchinov A.M., Umakhanova M.M., Duvansky R.A. et al. Photodynamic therapy of background and precancerous diseases of uterine cervix with photosensitisers of chlorine raw // Photodiagnosis and Photodynamic Therapy. - 2008. - Т. 5. - № S1. - P. 45.</mixed-citation><mixed-citation xml:lang="en">Torchinov A.M., Umakhanova M.M., Duvansky R.A. et al. Photodynamic therapy of background and precancerous diseases of uterine cervix with photosensitisers of chlorine raw // Photodiagnosis and Photodynamic Therapy. - 2008. - Т. 5. - № S1. - P. 45.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Tumlinson A.R., Barton J.K., Povazay B. et al. Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon // Opt. Express. - 2006. -14 (5). - P. 1878-1887.</mixed-citation><mixed-citation xml:lang="en">Tumlinson A.R., Barton J.K., Povazay B. et al. Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon // Opt. Express. - 2006. -14 (5). - P. 1878-1887.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tumlinson A.R., Hariri L.P., Utzinger U., Barton J.K. Miniature endoscope for simultaneous optical coherence tomography and laser-induced florescence measurement // Appl. Opt. - 2004. -43 (1). - P. 113-121.</mixed-citation><mixed-citation xml:lang="en">Tumlinson A.R., Hariri L.P., Utzinger U., Barton J.K. Miniature endoscope for simultaneous optical coherence tomography and laser-induced florescence measurement // Appl. Opt. - 2004. -43 (1). - P. 113-121.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Uedo N., Iishi H., Tatsuta M. et al. A novel video endoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers // Gastrointest. Endosc. - 2005. - 62. -P. 521-528.</mixed-citation><mixed-citation xml:lang="en">Uedo N., Iishi H., Tatsuta M. et al. A novel video endoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers // Gastrointest. Endosc. - 2005. - 62. -P. 521-528.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Broek F.J.C., Hardwick J.C.H., Reitsma J.B. et al. Autofluorescence imaging and narrow band imaging for the detection and classification of colonic polyps // Endoscopy. - 2007. -39 (suppl 1): A7 (abstract).</mixed-citation><mixed-citation xml:lang="en">Van den Broek F.J.C., Hardwick J.C.H., Reitsma J.B. et al. Autofluorescence imaging and narrow band imaging for the detection and classification of colonic polyps // Endoscopy. - 2007. -39 (suppl 1): A7 (abstract).</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace M.B., Fockens P. Probe-based confocal laser endomicroscopy // Gastroenterology. - 2009. - 136 (5). - P. 1509-13.</mixed-citation><mixed-citation xml:lang="en">Wallace M.B., Fockens P. Probe-based confocal laser endomicroscopy // Gastroenterology. - 2009. - 136 (5). - P. 1509-13.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wanders L.K., East J.E., Uitentuis S.E. et al. Diagnostic performance of narrowed spectrum endoscopy, autofluorescence imaging, and confocal laser endomicroscopy for optical diagnosis of colonic polyps: a metaanalysis // Lancet Oncol. - 2013. - 14. - P. 1337-1347.</mixed-citation><mixed-citation xml:lang="en">Wanders L.K., East J.E., Uitentuis S.E. et al. Diagnostic performance of narrowed spectrum endoscopy, autofluorescence imaging, and confocal laser endomicroscopy for optical diagnosis of colonic polyps: a metaanalysis // Lancet Oncol. - 2013. - 14. - P. 1337-1347.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y.W., Kang S., Khan A. et al. In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles // Biomed. Opt. Express. - 2015. - 6. -P. 3714-3723.</mixed-citation><mixed-citation xml:lang="en">Wang Y.W., Kang S., Khan A. et al. In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles // Biomed. Opt. Express. - 2015. - 6. -P. 3714-3723.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Z.G., Durand D.B., Schoenberg M., Pan Y.T. Fluorescence guided optical coherence tomography for the diagnosis of early bladder cancer in a rat model // J. Urol. - 2005. - 174 (6). - P. 2376-2381.</mixed-citation><mixed-citation xml:lang="en">Wang Z.G., Durand D.B., Schoenberg M., Pan Y.T. Fluorescence guided optical coherence tomography for the diagnosis of early bladder cancer in a rat model // J. Urol. - 2005. - 174 (6). - P. 2376-2381.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Winawer S.J., Zauber A.G., Ho M.N. et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993; 329: 1977-1981 [PMID: 8247072 DOI: 10.1056/NEJM199312303292701].</mixed-citation><mixed-citation xml:lang="en">Winawer S.J., Zauber A.G., Ho M.N. et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993; 329: 1977-1981 [PMID: 8247072 DOI: 10.1056/NEJM199312303292701].</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida N., Yagi N., Inada Y. et al. Ability of a novel blue laser imaging system for the diagnosis of colorectal polyps // Dig. Endosc. - 2014. - 26 (2). - P. 250-8. doi: 10.1111/den.12127.</mixed-citation><mixed-citation xml:lang="en">Yoshida N., Yagi N., Inada Y. et al. Ability of a novel blue laser imaging system for the diagnosis of colorectal polyps // Dig. Endosc. - 2014. - 26 (2). - P. 250-8. doi: 10.1111/den.12127.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan S., Li Q., Jiang J., Cable A., Chen Y. Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography // Opt. Lett. - 2009. -34 (11). - P. 1615-1617.</mixed-citation><mixed-citation xml:lang="en">Yuan S., Li Q., Jiang J., Cable A., Chen Y. Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography // Opt. Lett. - 2009. -34 (11). - P. 1615-1617.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao Zi-Ye et al. Detection and miss rates of autofluorescence imaging of adenomatous and polypoid lesions during colonoscopy: a systematic review and meta-analysis // Endosc. Int. Open. - 2015. - 03. - P. E226-E235.</mixed-citation><mixed-citation xml:lang="en">Zhao Zi-Ye et al. Detection and miss rates of autofluorescence imaging of adenomatous and polypoid lesions during colonoscopy: a systematic review and meta-analysis // Endosc. Int. Open. - 2015. - 03. - P. E226-E235.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
