The LED based product development conceptualizes the optical diagnostic technology with image processing for visualizing conditions that are characterized by increased risk for malignant transformation to Oral Squamous Cell Carcinoma (OSCC). The early detection and diagnosis is important for cancer prevention, disease treatment management and recovery progress monitoring, thus reducing the mortality of oral cancer. The proposed instrumentation will have modern LED/laser modules and optical design that lowers the cost. Two or more excitation and emission profiles are included in the design considerations. In concept, in vivo imaging with illumination technique resembles histological evaluations. Thus, clinical evaluations of oral lesions, real time identifications of tumor margins, disease treatment management, recovery progress monitoring is possible.